Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro

• Published in: European journal of pharmacology Vol. 912; p. 174566
• Main Authors: Yamamoto, Atsunori, Sagara, Ayumi, Otani, Kosuke, Okada, Muneyoshi, Yamawaki, Hideyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.12.2021
• Subjects: Acetylcysteine - pharmacology; Adipocytokine; Animals; Antioxidants - pharmacology; Cardiac fibroblasts; Cell Movement - drug effects; Chemokines - metabolism; Chemokines - pharmacology; Chromones - pharmacology; Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors; Extracellular Signal-Regulated MAP Kinases - metabolism; Fibroblasts - drug effects; Flavonoids - pharmacology; Male; Migration; Morpholines - pharmacology; Myocardium - cytology; Naphthalenes - pharmacology; Phosphorylation - drug effects; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - metabolism; Quaternary Ammonium Compounds - pharmacology; Rats; Rats, Wistar; Reactive Oxygen Species - metabolism; Receptors, Chemokine - antagonists & inhibitors; Receptors, Chemokine - metabolism; Adipocytokine; Cardiac fibroblasts; Migration

Since chemerin is an adipocytokine whose concentration in blood increases in the subjects with various cardiac diseases, chemerin may be involved in pathogenesis of cardiac diseases. In the present study, we examined the effects of chemerin-9, an active fragment of chemerin, on functions of cardiac...