Single-Molecule Study Reveals How Receptor and Ras Synergistically Activate PI3Kα and PIP3 Signaling

• Published in: Biophysical journal Vol. 113; no. 11; pp. 2396 - 2405
• Main Authors: Buckles, Thomas C., Ziemba, Brian P., Masson, Glenn R., Williams, Roger L., Falke, Joseph J.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.12.2017; The Biophysical Society
• Subjects: Membranes

Cellular pathways controlling chemotaxis, growth, survival, and oncogenesis are activated by receptor tyrosine kinases and small G-proteins of the Ras superfamily that stimulate specific isoforms of phosphatidylinositol-3-kinase (PI3K). These PI3K lipid kinases phosphorylate the constitutive lipid p...