Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes

• Published in: Science translational medicine Vol. 6; no. 265; p. 265ra169
• Main Authors: Hill, James M, Quenelle, Debra C, Cardin, Rhonda D, Vogel, Jodi L, Clement, Christian, Bravo, Fernando J, Foster, Timothy P, Bosch-Marce, Marta, Raja, Priya, Lee, Jennifer S, Bernstein, David I, Krause, Philip R, Knipe, David M, Kristie, Thomas M
• Format: Journal Article
• Language: English
• Published: United States 03.12.2014
• Subjects: Animals; Disease Models, Animal; Epigenesis, Genetic; Female; Genome, Viral; Guinea Pigs; Herpesviridae Infections - metabolism; Histone Demethylases; Mice; Mice, Inbred BALB C; Monoamine Oxidase Inhibitors - chemistry; Oxidoreductases, N-Demethylating - antagonists & inhibitors; Oxidoreductases, N-Demethylating - physiology; Phenotype; Protein Structure, Tertiary; Rabbits; Recurrence; Tranylcypromine - chemistry; Vagina - virology; Virus Activation; Virus Latency; Virus Replication - drug effects; Virus Shedding

Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latenc...