Genome Doubling Shapes High-Grade Transformation and Novel EWSR1::LARP4 Fusion Shows SOX10 Immunostaining in Hyalinizing Clear Cell Carcinoma of Salivary Gland

• Published in: Laboratory investigation Vol. 103; no. 10; p. 100213
• Main Authors: Kobayashi, Kenya, Kawazu, Masahito, Yoshimoto, Seiichi, Ueno, Toshihide, Omura, Go, Saito, Yuki, Ando, Mizuo, Ryo, Eigitsu, Sakyo, Airi, Yoshida, Akihiko, Yatabe, Yasushi, Mano, Hiroyuki, Mori, Taisuke
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2023
• Subjects: EWSR1; genome doubling; high-grade transformation; hyalinizing clear cell carcinoma; LARP4; novel fusion; hyalinizing clear cell carcinoma; novel fusion; genome doubling; LARP4; EWSR1; high-grade transformation

Hyalinizing clear cell carcinoma (HCCC) is a rare indolent malignant tumor of minor salivary gland origin with EWSR1::ATF1 rearrangement. Pathologically, the tumor cells possess a clear cytoplasm in a background of hyalinized stroma. Generally, the tumor cells are positive for p63 and p40 and negati...