Exploring the biological mechanisms of severe COVID-19 in the elderly: Insights from an aged mouse model

• Published in: Virulence Vol. 16; no. 1; p. 2487671
• Main Authors: Ma, Li, Lin, Xian, Xu, Meng, Ke, Xianliang, Liu, Di, Chen, Quanjiao
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Age Factors; Aged; aged mice; Aging; Animals; complement activation; COVID-19 - immunology; COVID-19 - pathology; COVID-19 - virology; Disease Models, Animal; Female; Gene Expression Profiling; Humans; immune response; Lung - immunology; Lung - pathology; Lung - virology; Male; Mice; Mice, Inbred C57BL; Proteome; Proteomics; SARS-CoV-2; SARS-CoV-2 - pathogenicity; Transcriptome; complement activation; SARS-CoV-2; immune response; transcriptome; aged mice; proteome

The elderly population, who have increased susceptibility to severe outcomes, have been particularly impacted by the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), leading to a global health crisis. However, definitive parameters or mechan...