Diverse polyubiquitin interaction properties of ubiquitin-associated domains

• Published in: Nature structural & molecular biology Vol. 12; no. 8; pp. 708 - 714
• Main Authors: Pickart, Cecile M, Raasi, Shahri, Varadan, Ranjani, Fushman, David
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.08.2005
• Subjects: Analysis; Cell Extracts - genetics; Glutathione Transferase; HeLa Cells; Humans; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Polyubiquitin - genetics; Polyubiquitin - metabolism; Protein Binding; Protein Structure, Tertiary; Saccharomycetales - genetics; Saccharomycetales - metabolism; Signal Transduction - genetics; Surface Plasmon Resonance; Surveys; Ubiquitin

The ubiquitin-associated (UBA) domain occurs frequently in proteins involved in ubiquitin-dependent signaling pathways. Although polyubiquitin chain binding is considered to be a defining feature of the UBA domain family, the generality of this property has not been established. Here we have surveye...