Causal impact of elevated body mass index on diabetic kidney disease: an integrated Mendelian randomization and Global Burden of Disease Study 2021 analysis

• Published in: Renal failure Vol. 47; no. 1; p. 2472981
• Main Authors: Chen, Ye-xin, Hu, Dong-sen, Lin, Mao-xuan, Gao, Zi-heng, Hong, Han-zhang, Hu, Yu-xin, Yao, Ling-zi, Cui, Gai-wen, Wang, Lin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Adult; Aged; Basic Sciences Investigations; Bayes Theorem; Body Mass Index; chronic kidney disease; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - epidemiology; diabetic kidney disease; Diabetic Nephropathies - epidemiology; Diabetic Nephropathies - etiology; Diabetic Nephropathies - mortality; Disability-Adjusted Life Years; elevated body mass index; Female; Global Burden of Disease - trends; Global Burden of Disease Study 2021; Global Health; Humans; Male; Mendelian Randomization; Mendelian Randomization Analysis; Middle Aged; Risk Factors; type 2 diabetes mellitus; diabetic kidney disease; type 2 diabetes mellitus; chronic kidney disease; Mendelian Randomization; Global Burden of Disease Study 2021; elevated body mass index

Elevated body mass index (BMI) has been implicated in the pathogenesis of diabetic kidney disease among patients with type 2 diabetes mellitus (T2DKD). However, establishing a causal relationship and quantifying the resultant global health impact remain challenging. A two-sample Mendelian randomizat...