Antitumour activity on extrinsic apoptotic targets of the triterpenoid maslinic acid in p53-deficient Caco-2 adenocarcinoma cells - Reyes-Zurita, Fernando J.; Rufino-Palomares, Eva E.; Medina, Pedro P.; Leticia García-Salguero, E.; Peragón, Juan; Cascante, Marta; Lupiáñez, José A. (Biochimie, 2013)
Keywords: adenocarcinoma; anticarcinogenic activity; apoptosis; Apoptosis - drug effects; bcl-2-Associated X Protein - biosynthesis; Caco-2 Cells; Caspase 3 - biosynthesis; Caspase 8 - biosynthesis; caspase-3; caspase-8; caspase-9; Colon cancer cells; colorectal neoplasms; etiology; Extrinsic apoptotic pathway; Gene Expression Regulation, Neoplastic - drug effects; HT29 Cells; human cell lines; Humans; JNK Mitogen-Activated Protein Kinases - biosynthesis; Maslinic acid; Mitochondria - metabolism; mitogen-activated protein kinase; Olea; Olea europaea; olive pomace; resistance mechanisms; Signal Transduction - drug effects; Triterpenes; Triterpenes - pharmacology; Triterpenes; Maslinic acid; DMSO; Extrinsic apoptotic pathway; DAPI; FACS; Rh123; DMEM; MMP; CDDO; MA; FCS; Colon cancer cells; PI; mitochondrial membrane potential; 4′,6-diamidino-2-phenylindole; fluorescence-activated cell sorter; Dulbecco's modified Eagle's medium; dimethyl sulfoxide; 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid; propidium iodide; foetal calf serum; rhodamine