Application and synthesis of thiazole ring in clinically approved drugs

• Published in: European journal of medicinal chemistry Vol. 250; p. 115172
• Main Authors: Niu, Zhen-Xi, Wang, Ya-Tao, Zhang, Sheng-Nan, Li, Yan, Chen, Xiao-Bing, Wang, Sai-Qi, Liu, Hong-Min
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 15.03.2023
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antifungal Agents - therapeutic use; Chemical synthesis; Clinical application; Heterocycles; Heterocyclic Compounds; Privileged scaffold; Thiazole ring; Thiazoles; Heterocycles; Thiazole ring; Chemical synthesis; Clinical application; Privileged scaffold

The development of heterocyclic derivatives has progressed considerably over the past few decades, and many new agents of synthetic and natural origin have been produced. Among heterocyclic compounds, thiazole is a unique five-membered heterocyclic motif characterized by nitrogen and sulfur atoms, w...