An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. T...

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Published inEuropean journal of medicinal chemistry Vol. 161; pp. 48 - 77
Main Authors Wang, Yijie, He, Jun, Liao, Mengya, Hu, Mingxing, Li, Wenzhen, Ouyang, Hongling, Wang, Xin, Ye, Tinghong, Zhang, Yiwen, Ouyang, Liang
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.01.2019
Subjects
Animals
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Modulators
Molecular Structure
Protein structures
Sirtuin family
Sirtuins - antagonists & inhibitors
Sirtuins - chemistry
Sirtuins - metabolism
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
Structure-Activity Relationship
Therapeutic potential
Protein structures
Therapeutic potential
Modulators
Sirtuin family
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Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies. [Display omitted] •The roles of Sirtuins are thoroughly discussed.•The functions of Sirtuins are outlined.•An overview for the modulators of Sirtuins is introduced in detail.
AbstractList Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD ), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.
Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies. [Display omitted] •The roles of Sirtuins are thoroughly discussed.•The functions of Sirtuins are outlined.•An overview for the modulators of Sirtuins is introduced in detail.
Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in the presence of nicotinamide adenine dinucleotide (NAD+), waves of research have assessed the potential of Sirtuin as a therapeutic target. The Sirtuin family, which is widely distributed throughout the nature, has been divided into seven human isoforms (Sirt1-Sirt7). They are thought to be closely related to some aging diseases such as cardiovascular disorders, neurodegeneration, and tumors. Herein, we present a comprehensive review of the structure, function and modulators of Sirtuins, which is expected to be beneficial to relevant studies.
Author Ye, Tinghong
Liao, Mengya
Wang, Xin
Zhang, Yiwen
He, Jun
Ouyang, Hongling
Ouyang, Liang
Hu, Mingxing
Wang, Yijie
Li, Wenzhen
Author_xml – sequence: 1
  givenname: Yijie
  surname: Wang
  fullname: Wang, Yijie
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 2
  givenname: Jun
  surname: He
  fullname: He, Jun
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 3
  givenname: Mengya
  surname: Liao
  fullname: Liao, Mengya
  organization: Sichuan Nursing Vocational College, Chengdu 610100, China
– sequence: 4
  givenname: Mingxing
  surname: Hu
  fullname: Hu, Mingxing
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 5
  givenname: Wenzhen
  surname: Li
  fullname: Li, Wenzhen
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 6
  givenname: Hongling
  surname: Ouyang
  fullname: Ouyang, Hongling
  organization: West China School of Pharmacy, Sichuan University, Chengdu 610041, China
– sequence: 7
  givenname: Xin
  surname: Wang
  fullname: Wang, Xin
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 8
  givenname: Tinghong
  surname: Ye
  fullname: Ye, Tinghong
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 9
  givenname: Yiwen
  orcidid: 0000-0002-4024-4881
  surname: Zhang
  fullname: Zhang, Yiwen
  email: yiwenzhang@scu.edu.cn
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
– sequence: 10
  givenname: Liang
  surname: Ouyang
  fullname: Ouyang, Liang
  email: ouyangliang@scu.edu.cn
  organization: State Key Laboratory of Biotherapy & Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu 610041, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30342425$$D View this record in MEDLINE/PubMed
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Snippet Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the 1970s. Because of its function by removing acetylated groups from histones in...
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SubjectTerms Animals
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Humans
Modulators
Molecular Structure
Protein structures
Sirtuin family
Sirtuins - antagonists & inhibitors
Sirtuins - chemistry
Sirtuins - metabolism
Small Molecule Libraries - chemistry
Small Molecule Libraries - pharmacology
Structure-Activity Relationship
Therapeutic potential
Title An overview of Sirtuins as potential therapeutic target: Structure, function and modulators
URI https://dx.doi.org/10.1016/j.ejmech.2018.10.028
https://www.ncbi.nlm.nih.gov/pubmed/30342425
https://www.proquest.com/docview/2123715652
Volume 161
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