Ciprofloxacin and the inner ear--a morphological and round window membrane permeability study

• Published in: O.R.L. Journal for oto-rhino-laryngology and its related specialties Vol. 54; no. 1; p. 5
• Main Authors: Bagger-Sjöbäck, D, Lundman, L, Nilsson-Ehle, I
• Format: Journal Article
• Language: English
• Published: Switzerland 1992
• Subjects: Animals; Chinchilla; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacokinetics; Ciprofloxacin - toxicity; Ear, Inner - drug effects; Ear, Inner - ultrastructure; Ear, Middle; Guinea Pigs; Microscopy, Electron, Scanning; Organ of Corti - drug effects; Organ of Corti - ultrastructure; Perilymph - chemistry; Permeability; Round Window, Ear - metabolism; Vestibule, Labyrinth - drug effects

This study was conducted in order to evaluate ototoxic potential and passage through the round window membrane of ciprofloxacin, a newly developed antimicrobial drug with an antibacterial spectrum well suited for the treatment of suppurative otitis media. Ciprofloxacin was injected intraperitoneally...