Misexpression of chick Vg1 in the marginal zone induces primitive streak formation

• Published in: Development (Cambridge) Vol. 124; no. 24; pp. 5127 - 5138
• Main Authors: Shah, S B, Skromne, I, Hume, C R, Kessler, D S, Lee, K J, Stern, C D, Dodd, J
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists Limited 01.12.1997
• Subjects: Animals; Blastoderm - chemistry; Chick Embryo; Cloning, Molecular; COS Cells; Culture Techniques; Embryonic Induction; Gastrula - chemistry; Gastrula - physiology; Gene Expression Regulation, Developmental - genetics; Glycoproteins - analysis; Glycoproteins - genetics; Glycoproteins - physiology; Recombinant Fusion Proteins; RNA, Messenger - analysis; Sequence Homology, Nucleic Acid; Transforming Growth Factor beta; Xenopus; Xenopus Proteins

In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vg1 (cVg1), a member of the TGFbeta family of signallin...