Misexpression of chick Vg1 in the marginal zone induces primitive streak formation
In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vg1 (cVg1), a member of the TGFbeta family of signallin...
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| Published in | Development (Cambridge) Vol. 124; no. 24; pp. 5127 - 5138 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
The Company of Biologists Limited
01.12.1997
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vg1 (cVg1), a member of the TGFbeta family of signalling molecules whose homolog in Xenopus is implicated in mesoderm induction, is expressed in the PMZ of prestreak embryos. Ectopic expression of cVg1 protein in the marginal zone chick blastoderms directs the formation of a secondary primitive streak, which subsequently develops into an ectopic embryo. We have used cell marking techniques to show that cells that contribute to the ectopic primitive streak change fate, acquiring two distinct properties of primitive streak cells, defined by gene expression and cell movements. Furthermore, naive epiblast explants exposed to cVg1 protein in vitro acquire axial mesodermal properties. Together, these results show that cVg1 can mediate ectopic axis formation in the chick by inducing new cell fates and they permit the analysis of distinct events that occur during primitive streak formation. |
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| AbstractList | In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vg1 (cVg1), a member of the TGF beta family of signalling molecules whose homolog in Xenopus is implicated in mesoderm induction, is expressed in the PMZ of prestreak embryos. Ectopic expression of cVg1 protein in the marginal zone chick blastoderms directs the formation of a secondary primitive streak, which subsequently develops into an ectopic embryo. We have used cell marking techniques to show that cells that contribute to the ectopic primitive streak change fate, acquiring two distinct properties of primitive streak cells, defined by gene expression and cell movements. Furthermore, naive epiblast explants exposed to cVg1 protein in vitro acquire axial mesodermal properties. Together, these results show that cVg1 can mediate ectopic axis formation in the chick by inducing new cell fates and they permit the analysis of distinct events that occur during primitive streak formation. ABSTRACT In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vgl (cVgl), a member of the TGFβ family of signalling molecules whose homolog in Xenopus is implicated in mesoderm induction, is expressed in the PMZ of prestreak embryos. Ectopic expression of cVg1 protein in the marginal zone chick blastoderms directs the formation of a secondary primitive streak, which subsequently develops into an ectopic embryo. We have used cell marking techniques to show that cells that contribute to the ectopic primitive streak change fate, acquiring two distinct properties of primitive streak cells, defined by gene expression and cell movements. Furthermore, naive epiblast explants exposed to cVg1 protein in vitro acquire axial mesodermal properties. Together, these results show that cVg1 can mediate ectopic axis formation in the chick by inducing new cell fates and they permit the analysis of distinct events that occur during primitive streak formation. In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida is influenced by the adjacent posterior marginal zone (PMZ). We show here that chick Vg1 (cVg1), a member of the TGFbeta family of signalling molecules whose homolog in Xenopus is implicated in mesoderm induction, is expressed in the PMZ of prestreak embryos. Ectopic expression of cVg1 protein in the marginal zone chick blastoderms directs the formation of a secondary primitive streak, which subsequently develops into an ectopic embryo. We have used cell marking techniques to show that cells that contribute to the ectopic primitive streak change fate, acquiring two distinct properties of primitive streak cells, defined by gene expression and cell movements. Furthermore, naive epiblast explants exposed to cVg1 protein in vitro acquire axial mesodermal properties. Together, these results show that cVg1 can mediate ectopic axis formation in the chick by inducing new cell fates and they permit the analysis of distinct events that occur during primitive streak formation. |
| Author | C.D. Stern D.S. Kessler K.J. Lee J. Dodd C.R. Hume I. Skromne S.B. Shah |
| Author_xml | – sequence: 1 givenname: S B surname: Shah fullname: Shah, S B organization: Department of Physiology and Cellular Biophysics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA – sequence: 2 givenname: I surname: Skromne fullname: Skromne, I – sequence: 3 givenname: C R surname: Hume fullname: Hume, C R – sequence: 4 givenname: D S surname: Kessler fullname: Kessler, D S – sequence: 5 givenname: K J surname: Lee fullname: Lee, K J – sequence: 6 givenname: C D surname: Stern fullname: Stern, C D – sequence: 7 givenname: J surname: Dodd fullname: Dodd, J |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9362470$$D View this record in MEDLINE/PubMed |
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| Snippet | In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area pellucida... ABSTRACT In the chick embryo, the primitive streak is the first axial structure to develop. The initiation of primitive streak formation in the posterior area... |
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| SubjectTerms | Animals Blastoderm - chemistry Chick Embryo Cloning, Molecular COS Cells Culture Techniques Embryonic Induction Gastrula - chemistry Gastrula - physiology Gene Expression Regulation, Developmental - genetics Glycoproteins - analysis Glycoproteins - genetics Glycoproteins - physiology Recombinant Fusion Proteins RNA, Messenger - analysis Sequence Homology, Nucleic Acid Transforming Growth Factor beta Xenopus Xenopus Proteins |
| Title | Misexpression of chick Vg1 in the marginal zone induces primitive streak formation |
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