Pharmacokinetics of Plasma 6-[18F]Fluoro-l-3,4-Dihydroxyphenylalanine ([18F]FDOPA) in Humans

• Published in: Journal of cerebral blood flow and metabolism Vol. 13; no. 4; pp. 668 - 675
• Main Authors: Cumming, Paul, Léger, Gabriel C., Kuwabara, Hiroto, Gjedde, Albert
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.1993
• Subjects: Adult; Arteries; Carbidopa - pharmacology; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine - analogs & derivatives; Dihydroxyphenylalanine - blood; Fluorine Radioisotopes; Humans; Parkinson Disease - blood; Reference Values; Tomography, Emission-Computed; O-Methyl-6-[18F]fluoro-l-DOPA; Metabolism; Positron emission tomography; Modeling; 6-[18F]Fluoro-l-DOPA

Like native DOPA, [18F]-6-fluoro-l-3,4-dihydroxyphenylalanine ([18F]FDOPA) is subject to methylation and decarboxylation. To determine the rates of formation and elimination of [18F]FDOPA metabolites, plasma from human subjects undergoing positron emission tomographic (PET) studies was analyzed by h...