MiR-223-3p regulates erythropoiesis by targeting TGFBR3/Smad signaling pathway in hemoglobin H-Constant Spring disease

• Published in: Annals of medicine (Helsinki) Vol. 57; no. 1; p. 2530690
• Main Authors: Lan, Lan, Wang, Xinyu, Zhang, Simeng, Zeng, Dan, Mo, Limin, Feng, Qiao, Li, Jun, Zhu, Chunjiang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Adult; Apoptosis - genetics; Case-Control Studies; Cell Proliferation; Down-Regulation; Erythropoiesis - genetics; Female; HbH-CS disease; Hematology; Humans; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miR-223-3p; Proteoglycans; Receptors, Transforming Growth Factor beta - genetics; Receptors, Transforming Growth Factor beta - metabolism; Signal Transduction - genetics; Smad2 Protein - genetics; Smad2 Protein - metabolism; Smad3 Protein - genetics; Smad3 Protein - metabolism; TGFBR3; Thalassemia; TGFBR3; Thalassemia; HbH-CS disease; miR-223-3p

MicroRNAs (miRNAs) have emerged as regulators of pathogenesis in hematopoiesis by targeting post-transcription mRNA regulation. However, the involvement of miRNAs in hemoglobin H-Constant Spring (HbH-CS) disease remains unclear. The present study analyzed miRNAs differential expression profile betwe...