Primary Prevention of Major Cardiovascular and Cerebrovascular Events with Statins in Diabetic Patients A Meta-Analysis

• Published in: Drugs (New York, N.Y.) Vol. 72; no. 18; pp. 2365 - 2373
• Main Authors: de Vries, Folgerdiena M., Denig, Petra, Pouwels, Koen B., Postma, Maarten J., Hak, Eelko
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 24.12.2012; Adis International
• Subjects: Biological and medical sciences; Cardiovascular Diseases - prevention & control; Cerebrovascular Disorders - prevention & control; Diabetes Mellitus - drug therapy; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; General and cellular metabolism. Vitamins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Internal Medicine; Medical sciences; Medicine; Medicine & Public Health; Pharmacology. Drug treatments; Pharmacology/Toxicology; Pharmacotherapy; Primary Prevention; Randomized Controlled Trials as Topic; Risk Factors; Systematic Review; Atorvastatin; Primary Prevention; Diabetic Patient; Statin; Simvastatin; Endocrinopathy; Human; Nervous system diseases; Diabetes mellitus; Mortality; Cardiovascular disease; Statin derivative; Review; Cerebral disorder; Metaanalysis; Prevention; Central nervous system disease; Primary; Complication; Cerebrovascular disease; Antilipemic agent

Background Patients with diabetes mellitus are at increased risk of developing cardiovascular disease. Controlling lipid levels has a preventive effect on the occurrence of major cardiovascular and cerebrovascular events. Individual trials have shown varying data on the efficacy of treatment with li...