Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer
Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have bee...
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| Published in | Biochimica et biophysica acta Vol. 1843; no. 9; pp. 1875 - 1885 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.09.2014
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| Abstract | Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have been used in clinical trials for cancer prevention and the treatment of diseases associated with oxidative stress; on the other hand, constitutive activation of NRF2 in many types of tumors contributes to the survival and growth of cancer cells, as well as resistance to anticancer therapy. In this review, we provide an overview of the NRF2 signaling pathway and discuss its role in carcinogenesis. We also introduce the inhibition of NRF2 by nuclear receptors. Further, we address the biological significance of regulation of the NRF2 signaling pathway by nuclear receptors in health and disease. Finally, we discuss the possible impact of NRF2 inhibition by nuclear receptors on cancer therapy.
•KEAP1–NRF2–ARE pathway•Role of NRF2 in cancer chemoprevention and carcinogenesis•Repression of NRF2 by nuclear receptors•Therapeutic perspective of NRF2 inhibition through nuclear receptors |
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| AbstractList | Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have been used in clinical trials for cancer prevention and the treatment of diseases associated with oxidative stress; on the other hand, constitutive activation of NRF2 in many types of tumors contributes to the survival and growth of cancer cells, as well as resistance to anticancer therapy. In this review, we provide an overview of the NRF2 signaling pathway and discuss its role in carcinogenesis. We also introduce the inhibition of NRF2 by nuclear receptors. Further, we address the biological significance of regulation of the NRF2 signaling pathway by nuclear receptors in health and disease. Finally, we discuss the possible impact of NRF2 inhibition by nuclear receptors on cancer therapy.
•KEAP1–NRF2–ARE pathway•Role of NRF2 in cancer chemoprevention and carcinogenesis•Repression of NRF2 by nuclear receptors•Therapeutic perspective of NRF2 inhibition through nuclear receptors Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays a critical role in regulating cellular defense against electrophilic and oxidative stress by activating the expression of an array of antioxidant response element-dependent genes. On one hand, NRF2 activators have been used in clinical trials for cancer prevention and the treatment of diseases associated with oxidative stress; on the other hand, constitutive activation of NRF2 in many types of tumors contributes to the survival and growth of cancer cells, as well as resistance to anticancer therapy. In this review, we provide an overview of the NRF2 signaling pathway and discuss its role in carcinogenesis. We also introduce the inhibition of NRF2 by nuclear receptors. Further, we address the biological significance of regulation of the NRF2 signaling pathway by nuclear receptors in health and disease. Finally, we discuss the possible impact of NRF2 inhibition by nuclear receptors on cancer therapy. |
| Author | Wang, Xiu Jun Tang, Xiuwen Li, Yulong Namani, Akhileshwar |
| Author_xml | – sequence: 1 givenname: Akhileshwar surname: Namani fullname: Namani, Akhileshwar organization: Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058, PR China – sequence: 2 givenname: Yulong surname: Li fullname: Li, Yulong organization: Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058, PR China – sequence: 3 givenname: Xiu Jun orcidid: 0000-0001-7516-4606 surname: Wang fullname: Wang, Xiu Jun email: xjwang@zju.edu.cn organization: Department of Pharmacology, Zhejiang University School of Medicine, Hangzhou 310058, PR China – sequence: 4 givenname: Xiuwen surname: Tang fullname: Tang, Xiuwen email: xiuwentang@zju.edu.cn organization: Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24851839$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/j.addr.2010.07.003 10.1007/s10549-010-1023-8 10.1128/MCB.00753-07 10.1038/nrd1551 10.1016/j.freeradbiomed.2012.12.014 10.1007/BF03401947 10.1371/journal.pmed.0030420 10.1016/j.bbamcr.2012.06.012 10.1016/j.bbrc.2007.08.051 10.1091/mbc.E12-09-0666 10.1128/MCB.24.17.7681-7694.2004 10.1016/j.bbrc.2011.09.014 10.1097/IGC.0b013e31822d0eb2 10.1053/j.gastro.2008.06.082 10.1038/onc.2012.388 10.1371/journal.pone.0073794 10.1172/JCI66353 10.1016/j.molcel.2009.04.029 10.1016/j.freeradbiomed.2007.03.001 10.2174/156802612799436641 10.1124/pr.58.4.4 10.1128/MCB.01704-07 10.1124/pr.58.4.2 10.1038/nrd2397 10.1158/0008-5472.CAN-09-2223 10.1089/ars.2011.4414 10.1073/pnas.93.25.14960 10.1038/sj.onc.1204506 10.1006/geno.1994.1193 10.1158/1078-0432.CCR-08-2822 10.1074/jbc.M403061200 10.1593/neo.11750 10.1089/ars.2010.3221 10.1158/0008-5472.CAN-07-5003 10.1126/science.1133427 10.1101/gr.2160004 10.1016/j.devcel.2007.07.011 10.1046/j.1365-2443.2001.00469.x 10.1101/gad.13.1.76 10.1128/MCB.26.8.2887-2900.2006 10.1006/bbrc.1997.6943 10.1038/sj.onc.1210986 10.1007/s11095-010-0096-8 10.1016/j.jmb.2007.11.074 10.1002/path.2653 10.1242/jcs.095422 10.1038/onc.2012.493 10.1073/pnas.1014275108 10.1038/ncb2021 10.1074/jbc.M110.118976 10.1124/pr.58.4.9 10.1007/s00280-009-1140-4 10.1074/jbc.M109.096545 10.1128/MCB.25.10.4150-4165.2005 10.1128/MCB.24.24.10941-10953.2004 10.1093/nar/gks409 10.1038/nm.3159 10.1210/en.2003-0817 10.2174/15680266113139990006 10.1074/jbc.M605707200 10.1158/1535-7163.MCT-09-0589 10.1158/0008-5472.CAN-12-4400 10.1016/j.mod.2004.01.006 10.1111/j.1755-148X.2011.00913.x 10.4161/epi.6.3.14408 10.1038/jhg.2010.172 10.1016/S1043-2760(02)00592-1 10.1007/s00018-008-7452-4 10.1073/pnas.1000102107 10.1038/nature10888 10.1093/carcin/bgm049 10.1007/s11033-011-1266-4 10.1128/MCB.25.1.162-171.2005 10.1093/carcin/bgq105 10.1074/jbc.M110.121913 10.1073/pnas.051618798 10.1073/pnas.0709483104 10.1002/med.21257 10.1016/j.cbi.2013.08.008 10.1016/j.bbrc.2008.06.004 10.1074/jbc.M111.316471 10.1016/j.jaci.2013.09.007 10.1016/j.mce.2005.08.002 10.1172/JCI27987 10.1186/1471-2407-12-66 10.2174/156652407781695765 10.1158/1535-7163.MCT-05-0497 10.1016/j.abb.2004.10.012 10.1158/0008-5472.CAN-06-0300 10.1016/j.freeradbiomed.2011.03.008 10.1038/42022 10.1016/j.bbalip.2011.09.014 10.1089/ars.2010.3222 10.1016/j.ccr.2012.05.016 10.1128/MCB.06271-11 10.1038/375203a0 10.1038/cdd.2010.114 10.1073/pnas.220418997 10.1073/pnas.0806268105 10.1128/MCB.25.24.10895-10906.2005 10.1074/jbc.M109.051714 10.2174/156802612799436687 10.1038/331091a0 10.1074/jbc.M602746200 10.1093/nar/gkq212 10.1128/MCB.00708-09 10.1371/journal.pone.0036774 10.1016/j.bbamcr.2008.05.024 10.1016/j.mce.2007.08.011 10.1089/ars.2010.3219 10.1073/pnas.172398899 10.1158/0008-5472.CAN-08-1401 10.1007/s10549-011-1604-1 10.1158/1535-7163.MCT-10-0108 10.2174/092986711795029618 10.1073/pnas.91.21.9926 10.1021/tx7002883 10.1074/jbc.M002319200 10.1158/0008-5472.CAN-12-3386 10.1146/annurev.med.53.082901.104018 10.1128/MCB.00248-10 10.1074/jbc.M500166200 10.1186/1477-3163-5-14 10.1016/j.gassur.2004.02.007 10.1158/0008-5472.CAN-04-1906 10.1074/jbc.M206530200 10.1074/jbc.M111.312694 10.1158/0008-5472.CAN-10-0384 10.1016/j.mce.2010.06.018 10.1128/MCB.01204-10 10.1158/1535-7163.MCT-08-0625 10.4161/epi.23319 10.1038/onc.2012.59 10.1038/nature10189 10.1074/jbc.M111.275495 10.1124/pr.58.4.7 10.1182/blood-2009-04-214817 10.1016/j.tips.2013.04.005 10.1093/carcin/bgt108 10.1073/pnas.0307301101 10.1093/carcin/bgn095 10.1016/j.mce.2011.08.033 10.1530/JME-13-0150 10.1002/jbt.20212 10.1016/j.taap.2013.03.029 10.1016/j.mce.2011.07.025 10.1128/MCB.00065-13 10.1006/taap.2001.9176 10.1093/carcin/bgi006 10.1021/tx0502138 10.1146/annurev.physiol.69.031905.160308 10.1016/j.freeradbiomed.2010.09.006 10.4161/epi.6.6.15773 10.1111/j.1439-0396.2008.00838.x 10.1158/0008-5472.CAN-07-2170 10.1016/j.molcel.2006.01.013 |
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| Keywords | Bcl-2 RAR Nuclear receptor Neh7 RXRα DBD KEAP1 ChIP TXS BBN DPP3 CBP NRF2 PPAR SNP miRNA 11β-HSD1 GSH NQO1 Bach1 ERα GST GR β-TrCP AKR1C ERRβ Neh Bcl-xL ARE Dex Cancer therapy ROS SMRT ATRA |
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| References | Chorley, Campbell, Wang, Karaca, Sambandan, Bangura, Xue, Pi, Kleeberger, Bell (bb0275) 2012; 40 Sjoblom, Jones, Wood, Parsons, Lin, Barber, Mandelker, Leary, Ptak, Silliman, Szabo, Buckhaults, Farrell, Meeh, Markowitz, Willis, Dawson, Willson, Gazdar, Hartigan, Wu, Liu, Parmigiani, Park, Bachman, Papadopoulos, Vogelstein, Kinzler, Velculescu (bb0435) 2006; 314 Moi, Chan, Asunis, Cao, Kan (bb0020) 1994; 91 Hong, Freeman, Liebler (bb0175) 2005; 18 Kim, Yu, Chen, Kong (bb0110) 2013; 32 Hatcher, Planalp, Cho, Torti, Torti (bb0330) 2008; 65 Gronemeyer, Gustafsson, Laudet (bb0795) 2004; 3 Hanada, Takahata, Zhou, Ye, Sun, Itoh, Ishiguro, Kijima, Mimura, Itoh, Fukuda, Saijo (bb0475) 2012; 12 Rada, Rojo, Chowdhry, McMahon, Hayes, Cuadrado (bb0125) 2011; 31 Berger, Moller (bb0595) 2002; 53 Plafker, Nguyen, Barneche, Mirza, Crawford, Plafker (bb0085) 2010; 285 Apopa, He, Ma (bb0210) 2008; 22 Boesch-Saadatmandi, Wagner, Graeser, Hundhausen, Wolffram, Rimbach (bb0760) 2009; 93 Suzuki, Shibata, Takaya, Shiraishi, Kohno, Kunitoh, Tsuta, Furuta, Goto, Hosoda, Sakamoto, Motohashi, Yamamoto (bb0485) 2013; 33 Kundu, Surh (bb0030) 2010; 27 Satoh, Moriguchi, Taguchi, Takai, Maher, Suzuki, Winnard, Raman, Ebina, Nukiwa, Yamamoto (bb0315) 2010; 31 Brown, Sekhar, Rachakonda, Sasi, Freeman (bb0745) 2008; 68 Germain, Staels, Dacquet, Spedding, Laudet (bb0495) 2006; 58 Ohta, Iijima, Miyamoto, Nakahara, Tanaka, Ohtsuji, Suzuki, Kobayashi, Yokota, Sakiyama, Shibata, Yamamoto, Hirohashi (bb0430) 2008; 68 Jain, Lamark, Sjottem, Larsen, Awuh, Overvatn, McMahon, Hayes, Johansen (bb0230) 2010; 285 Yu, Wong, Wang, Ling, Ng, Chen, Chan (bb0665) 2008; 27 Katoh, Iida, Kang, Kobayashi, Mizukami, Tong, McMahon, Hayes, Itoh, Yamamoto (bb0095) 2005; 433 Dhakshinamoorthy, Jaiswal (bb0140) 2001; 20 Huang, Nguyen, Pickett (bb0195) 2000; 97 Furukawa, Xiong (bb0050) 2005; 25 Thimmulappa, Mai, Srisuma, Kensler, Yamamoto, Biswal (bb0025) 2002; 62 Watson, Fairall, Schwabe (bb0550) 2012; 348 Zhang, Singh, Yegnasubramanian, Esopi, Kombairaju, Bodas, Wu, Bova, Biswal (bb0385) 2010; 9 Muscarella, Barbano, D'Angelo, Copetti, Coco, Balsamo, la Torre, Notarangelo, Troiano, Parisi, Icolaro, Catapano, Valori, Pellegrini, Merla, Carella, Fazio, Parrella (bb0470) 2011; 6 Dawson, Xia (bb0585) 2012; 1821 Venugopal, Jaiswal (bb0285) 1996; 93 Helsen, Kerkhofs, Clinckemalie, Spans, Laurent, Boonen, Vanderschueren, Claessens (bb0700) 2012; 348 Singh, Wu, Zhang, Happel, Ma, Biswal (bb0345) 2010; 9 Shibata, Kokubu, Saito, Narisawa-Saito, Sasaki, Aoyagi, Yoshimatsu, Tachimori, Kushima, Kiyono, Yamamoto (bb0405) 2011; 13 Bushue, Wan (bb0535) 2010; 62 Ahmadian, Suh, Hah, Liddle, Atkins, Downes, Evans (bb0600) 2013; 19 Kim, Oh, Kim, Kang, Park, Han, Eom, Yoo, Lee (bb0400) 2010; 220 Germain, Chambon, Eichele, Evans, Lazar, Leid, De Lera, Lotan, Mangelsdorf, Gronemeyer (bb0575) 2006; 58 Ohnuma, Matsumoto, Itoi, Kawana, Nishiyama, Ogura, Hiratsuka (bb0775) 2011; 413 Gao, Ke, Wang, Yang, Chen, Chen (bb0780) 2013; 34 McMahon, Thomas, Itoh, Yamamoto, Hayes (bb0120) 2004; 279 Wakabayashi, Dinkova-Kostova, Holtzclaw, Kang, Kobayashi, Yamamoto, Kensler, Talalay (bb0065) 2004; 101 Lau, Wang, Zhao, Villeneuve, Wu, Jiang, Sun, White, Zhang (bb0235) 2010; 30 Giguere, Yang, Segui, Evans (bb0640) 1988; 331 Muscarella, Parrella, D'Alessandro, la Torre, Barbano, Fontana, Tancredi, Guarnieri, Balsamo, Coco, Copetti, Pellegrini, De Bonis, Bisceglia, Scaramuzzi, Maiello, Valori, Merla, Vendemiale, Fazio (bb0465) 2011; 6 Qu, Tang (bb0590) 2010; 65 Li, Huang, Yi, Bambara, Hilf, Muyan (bb0610) 2004; 24 Krishnan, Nair, Pillai (bb0725) 2007; 7 Hu, Ju, Lin, Wang, Huang, Zhang, Wu, Jiao (bb0415) 2012; 39 Giguere (bb0645) 2002; 13 Hayes, McMahon, Chowdhry, Dinkova-Kostova (bb0150) 2010; 13 Homma, Ishii, Morishima, Yamadori, Matsuno, Haraguchi, Kikuchi, Satoh, Sakamoto, Hizawa, Itoh, Yamamoto (bb0380) 2009; 15 Wang, Hayes, Henderson, Wolf (bb0570) 2007; 104 Lo, Matthews (bb0635) 2013; 270 Bensasson, Zoete, Dinkova-Kostova, Talalay (bb0185) 2008; 21 Ansell, Espinosa-Nicholas, Curran, Judy, Philips, Hannink, Lubahn (bb0620) 2004; 145 Zhou, Lo, Liu, Hannink, Lubahn (bb0675) 2007; 278 Gupta, Hevia, Patchva, Park, Koh, Aggarwal (bb0010) 2012; 16 Lu, Wardell, Burnstein, Defranco, Fuller, Giguere, Hochberg, McKay, Renoir, Weigel, Wilson, McDonnell, Cidlowski (bb0680) 2006; 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21 Wang (10.1016/j.bbamcr.2014.05.003_bb0135) 2013; 73 Wang (10.1016/j.bbamcr.2014.05.003_bb0340) 2008; 29 Pawlak (10.1016/j.bbamcr.2014.05.003_bb0525) 2012; 12 Wang (10.1016/j.bbamcr.2014.05.003_bb0570) 2007; 104 Huang (10.1016/j.bbamcr.2014.05.003_bb0195) 2000; 97 Chorley (10.1016/j.bbamcr.2014.05.003_bb0275) 2012; 40 Ansell (10.1016/j.bbamcr.2014.05.003_bb0625) 2005; 243 Gupta (10.1016/j.bbamcr.2014.05.003_bb0010) 2012; 16 Reuter (10.1016/j.bbamcr.2014.05.003_bb0015) 2010; 49 Shibata (10.1016/j.bbamcr.2014.05.003_bb0410) 2010; 70 Wong (10.1016/j.bbamcr.2014.05.003_bb0450) 2011; 21 Dey (10.1016/j.bbamcr.2014.05.003_bb0615) 2013; 51 Giguere (10.1016/j.bbamcr.2014.05.003_bb0640) 1988; 331 Giguere (10.1016/j.bbamcr.2014.05.003_bb0510) 1999; 20 Chen (10.1016/j.bbamcr.2014.05.003_bb0660) 2007; 13 Tang (10.1016/j.bbamcr.2014.05.003_bb0765) 2011; 50 Zipper (10.1016/j.bbamcr.2014.05.003_bb0045) 2002; 277 Zhang (10.1016/j.bbamcr.2014.05.003_bb0515) 2004; 14 Wakabayashi (10.1016/j.bbamcr.2014.05.003_bb0065) 2004; 101 Xu (10.1016/j.bbamcr.2014.05.003_bb0200) 2006; 5 Rastinejad (10.1016/j.bbamcr.2014.05.003_bb0500) 1995; 375 Katoh (10.1016/j.bbamcr.2014.05.003_bb0105) 2001; 6 Pi (10.1016/j.bbamcr.2014.05.003_bb0205) 2007; 42 Zhang (10.1016/j.bbamcr.2014.05.003_bb0335) 2008; 7 Ohnuma (10.1016/j.bbamcr.2014.05.003_bb0775) 2011; 413 Mitsunaga (10.1016/j.bbamcr.2014.05.003_bb0655) 2004; 121 Shibata (10.1016/j.bbamcr.2014.05.003_bb0405) 2011; 13 Germain (10.1016/j.bbamcr.2014.05.003_bb0495) 2006; 58 Singh (10.1016/j.bbamcr.2014.05.003_bb0375) 2008; 68 Plafker (10.1016/j.bbamcr.2014.05.003_bb0085) 2010; 285 Altucci (10.1016/j.bbamcr.2014.05.003_bb0565) 2007; 6 Hu (10.1016/j.bbamcr.2014.05.003_bb0415) 2012; 39 O'Malley (10.1016/j.bbamcr.2014.05.003_bb0555) 2009; 69 Sjoblom (10.1016/j.bbamcr.2014.05.003_bb0435) 2006; 314 Aoki (10.1016/j.bbamcr.2014.05.003_bb0310) 2001; 173 Lau (10.1016/j.bbamcr.2014.05.003_bb0235) 2010; 30 Ikeda (10.1016/j.bbamcr.2014.05.003_bb0605) 2000; 275 Suzuki (10.1016/j.bbamcr.2014.05.003_bb0485) 2013; 33 Tong (10.1016/j.bbamcr.2014.05.003_bb0090) 2006; 26 Kurokawa (10.1016/j.bbamcr.2014.05.003_bb0160) 2009; 29 Kundu (10.1016/j.bbamcr.2014.05.003_bb0030) 2010; 27 Chen (10.1016/j.bbamcr.2014.05.003_bb0215) 2009; 34 Furukawa (10.1016/j.bbamcr.2014.05.003_bb0050) 2005; 25 Cornblatt (10.1016/j.bbamcr.2014.05.003_bb0325) 2007; 28 Gao (10.1016/j.bbamcr.2014.05.003_bb0780) 2013; 34 Yang (10.1016/j.bbamcr.2014.05.003_bb0265) 2011; 129 Nioi (10.1016/j.bbamcr.2014.05.003_bb0440) 2007; 362 Itoh (10.1016/j.bbamcr.2014.05.003_bb0070) 1999; 13 Xiao (10.1016/j.bbamcr.2014.05.003_bb0520) 2013; 13 Berger (10.1016/j.bbamcr.2014.05.003_bb0595) 2002; 53 Ki (10.1016/j.bbamcr.2014.05.003_bb0690) 2005; 25 Zhang (10.1016/j.bbamcr.2014.05.003_bb0385) 2010; 9 Barbano (10.1016/j.bbamcr.2014.05.003_bb0480) 2013; 8 Hast (10.1016/j.bbamcr.2014.05.003_bb0250) 2013; 73 Chowdhry (10.1016/j.bbamcr.2014.05.003_bb0130) 2013; 32 Hong (10.1016/j.bbamcr.2014.05.003_bb0175) 2005; 18 Satoh (10.1016/j.bbamcr.2014.05.003_bb0315) 2010; 31 Li (10.1016/j.bbamcr.2014.05.003_bb0455) 2011; 56 |
| References_xml | – volume: 58 start-page: 685 year: 2006 end-page: 704 ident: bb0495 article-title: Overview of nomenclature of nuclear receptors publication-title: Pharmacol. Rev. contributor: fullname: Laudet – volume: 51 start-page: T61 year: 2013 end-page: T74 ident: bb0615 article-title: Insight into the mechanisms of action of estrogen receptor beta in the breast, prostate, colon, and CNS publication-title: J. Mol. Endocrinol. contributor: fullname: Gustafsson – volume: 62 start-page: 1285 year: 2010 end-page: 1298 ident: bb0535 article-title: Retinoid pathway and cancer therapeutics publication-title: Adv. Drug Deliv. Rev. contributor: fullname: Wan – volume: 285 start-page: 8463 year: 2010 end-page: 8471 ident: bb0180 article-title: Activation of NRF2 by nitrosative agents and H publication-title: J. Biol. Chem. contributor: fullname: Toledano – volume: 26 start-page: 525 year: 2005 end-page: 530 ident: bb0715 article-title: Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis publication-title: Carcinogenesis contributor: fullname: Schneider – volume: 25 start-page: 10895 year: 2005 end-page: 10906 ident: bb0100 article-title: The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation publication-title: Mol. Cell. Biol. contributor: fullname: Pickett – volume: 39 start-page: 4743 year: 2012 end-page: 4747 ident: bb0415 article-title: Mutation of the Nrf2 gene in non-small cell lung cancer publication-title: Mol. Biol. Rep. contributor: fullname: Jiao – volume: 19 start-page: 557 year: 2013 end-page: 566 ident: bb0600 article-title: PPARgamma signaling and metabolism: the good, the bad and the future publication-title: Nat. Med. contributor: fullname: Evans – volume: 13 start-page: 1713 year: 2010 end-page: 1748 ident: bb0150 article-title: Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway publication-title: Antioxid. Redox Signal. contributor: fullname: Dinkova-Kostova – volume: 8 start-page: e73794 year: 2013 ident: bb0490 article-title: SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women publication-title: PLoS ONE contributor: fullname: Ishikawa – volume: 50 start-page: 1599 year: 2011 end-page: 1609 ident: bb0765 article-title: Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs publication-title: Free Radic. Biol. Med. contributor: fullname: Wang – volume: 25 start-page: 162 year: 2005 end-page: 171 ident: bb0050 article-title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase publication-title: Mol. Cell. Biol. contributor: fullname: Xiong – volume: 69 start-page: 201 year: 2007 end-page: 220 ident: bb0530 article-title: Nuclear receptor structure: implications for function publication-title: Annu. Rev. Physiol. contributor: fullname: Miura – volume: 31 start-page: 1833 year: 2010 end-page: 1843 ident: bb0315 article-title: Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung publication-title: Carcinogenesis contributor: fullname: Yamamoto – volume: 388 start-page: 778 year: 1997 end-page: 782 ident: bb0650 article-title: Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta publication-title: Nature contributor: fullname: Giguere – volume: 91 start-page: 9926 year: 1994 end-page: 9930 ident: bb0020 article-title: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kan – volume: 93 start-page: 14960 year: 1996 end-page: 14965 ident: bb0285 article-title: Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Jaiswal – volume: 22 start-page: 66 year: 2012 end-page: 79 ident: bb0360 article-title: Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming publication-title: Cancer Cell contributor: fullname: Motohashi – volume: 7 start-page: e36774 year: 2012 ident: bb0695 article-title: Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11beta-HSD1-mediated glucocorticoid activation in hepatic cells publication-title: PLoS ONE contributor: fullname: Odermatt – volume: 135 start-page: 1358 year: 2008 end-page: 1368 ident: bb0445 article-title: Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer publication-title: Gastroenterology contributor: fullname: Hirohashi – volume: 275 start-page: 33142 year: 2000 end-page: 33150 ident: bb0605 article-title: Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2 publication-title: J. Biol. Chem. contributor: fullname: Takeuchi – volume: 413 start-page: 623 year: 2011 end-page: 629 ident: bb0775 article-title: Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Hiratsuka – volume: 32 start-page: 687 year: 2012 end-page: 726 ident: bb0320 article-title: Small molecule modulators of Keap1–Nrf2–ARE pathway as potential preventive and therapeutic agents publication-title: Med. Res. Rev. contributor: fullname: Hu – volume: 9 start-page: 336 year: 2010 end-page: 346 ident: bb0385 article-title: Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth publication-title: Mol. Cancer Ther. contributor: fullname: Biswal – volume: 105 start-page: 13568 year: 2008 end-page: 13573 ident: bb0395 article-title: Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Hirohashi – volume: 73 start-page: 2199 year: 2013 end-page: 2210 ident: bb0250 article-title: Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination publication-title: Cancer Res. contributor: fullname: Major – volume: 277 start-page: 36544 year: 2002 end-page: 36552 ident: bb0045 article-title: The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm publication-title: J. Biol. Chem. contributor: fullname: Mulcahy – volume: 18 start-page: 1405 year: 2011 end-page: 1412 ident: bb0540 article-title: Regulation of gene expression by retinoids publication-title: Curr. Med. Chem. contributor: fullname: Bazhin – volume: 58 start-page: 760 year: 2006 end-page: 772 ident: bb0575 article-title: International Union of Pharmacology. LXIII. Retinoid X receptors publication-title: Pharmacol. Rev. contributor: fullname: Gronemeyer – volume: 6 start-page: 317 year: 2011 end-page: 325 ident: bb0470 article-title: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome publication-title: Epigenetics contributor: fullname: Parrella – volume: 7 start-page: 532 year: 2007 end-page: 540 ident: bb0725 article-title: Biology of PPAR gamma in cancer: a critical review on existing lacunae publication-title: Curr. Mol. Med. contributor: fullname: Pillai – volume: 285 start-page: 22576 year: 2010 end-page: 22591 ident: bb0230 article-title: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription publication-title: J. Biol. Chem. contributor: fullname: Johansen – volume: 25 start-page: 4150 year: 2005 end-page: 4165 ident: bb0690 article-title: Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression publication-title: Mol. Cell. Biol. contributor: fullname: Kim – volume: 68 start-page: 7975 year: 2008 end-page: 7984 ident: bb0375 article-title: RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy publication-title: Cancer Res. contributor: fullname: Biswal – volume: 121 start-page: 237 year: 2004 end-page: 246 ident: bb0655 article-title: Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos publication-title: Mech. Dev. contributor: fullname: Abe – volume: 286 start-page: 40725 year: 2011 end-page: 40733 ident: bb0270 article-title: miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells publication-title: J. Biol. Chem. contributor: fullname: Zhou – volume: 375 start-page: 203 year: 1995 end-page: 211 ident: bb0500 article-title: Structural determinants of nuclear receptor assembly on DNA direct repeats publication-title: Nature contributor: fullname: Sigler – volume: 8 start-page: 413 year: 2004 end-page: 422 ident: bb0710 article-title: Role of retinoid X receptor mRNA expression in Barrett's esophagus publication-title: J. Gastrointest. Surg. contributor: fullname: Schneider – volume: 373 start-page: 151 year: 2008 end-page: 154 ident: bb0460 article-title: Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Zhou – volume: 1823 start-page: 1841 year: 2012 end-page: 1846 ident: bb0165 article-title: The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives publication-title: Biochim. Biophys. Acta contributor: fullname: Blank – volume: 108 start-page: 1433 year: 2011 end-page: 1438 ident: bb0770 article-title: Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Zhang – volume: 9 start-page: 2365 year: 2010 end-page: 2376 ident: bb0345 article-title: Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype publication-title: Mol. Cancer Ther. contributor: fullname: Biswal – volume: 34 start-page: 663 year: 2009 end-page: 673 ident: bb0215 article-title: Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response publication-title: Mol. Cell contributor: fullname: Zhang – volume: 31 start-page: 1121 year: 2011 end-page: 1133 ident: bb0125 article-title: SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner publication-title: Mol. Cell. Biol. contributor: fullname: Cuadrado – volume: 6 start-page: 710 year: 2011 end-page: 719 ident: bb0465 article-title: Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer publication-title: Epigenetics contributor: fullname: Fazio – volume: 107 start-page: 11579 year: 2010 end-page: 11584 ident: bb0670 article-title: The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Blackshaw – volume: 5 start-page: 1918 year: 2006 end-page: 1926 ident: bb0200 article-title: Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2 publication-title: Mol. Cancer Ther. contributor: fullname: Kong – volume: 33 start-page: 2402 year: 2013 end-page: 2412 ident: bb0485 article-title: Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 26 start-page: 2887 year: 2006 end-page: 2900 ident: bb0090 article-title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 101 start-page: 2040 year: 2004 end-page: 2045 ident: bb0065 article-title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Talalay – volume: 73 start-page: 3097 year: 2013 end-page: 3108 ident: bb0135 article-title: RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2 publication-title: Cancer Res. contributor: fullname: Tang – volume: 243 start-page: 27 year: 2005 end-page: 34 ident: bb0625 article-title: Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha publication-title: Mol. Cell. Endocrinol. contributor: fullname: Lubahn – volume: 116 start-page: 4338 year: 2010 end-page: 4348 ident: bb0260 article-title: MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease publication-title: Blood contributor: fullname: Chi – volume: 13 start-page: 1192 year: 2013 end-page: 1200 ident: bb0520 article-title: Recent progresses in identifying nuclear receptors and their families publication-title: Curr. Top. Med. Chem. contributor: fullname: Chou – volume: 29 start-page: 1235 year: 2008 end-page: 1243 ident: bb0340 article-title: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 publication-title: Carcinogenesis contributor: fullname: Zhang – volume: 123 start-page: 2921 year: 2013 end-page: 2934 ident: bb0280 article-title: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis publication-title: J. Clin. Invest. contributor: fullname: Biswal – volume: 34 start-page: 1806 year: 2013 end-page: 1814 ident: bb0780 article-title: Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway publication-title: Carcinogenesis contributor: fullname: Chen – volume: 285 start-page: 16782 year: 2010 end-page: 16788 ident: bb0220 article-title: Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1–Nrf2 cell defense pathway publication-title: J. Biol. Chem. contributor: fullname: Park – volume: 21 start-page: 1428 year: 2011 end-page: 1435 ident: bb0450 article-title: Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival publication-title: Int. J. Gynecol. Cancer contributor: fullname: Yaegashi – volume: 287 start-page: 6539 year: 2012 end-page: 6550 ident: bb0240 article-title: Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein publication-title: J. Biol. Chem. contributor: fullname: Moon – volume: 285 start-page: 23064 year: 2010 end-page: 23074 ident: bb0085 article-title: The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2 publication-title: J. Biol. Chem. contributor: fullname: Plafker – volume: 18 start-page: 1917 year: 2005 end-page: 1926 ident: bb0175 article-title: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane publication-title: Chem. Res. Toxicol. contributor: fullname: Liebler – volume: 22 start-page: 63 year: 2008 end-page: 76 ident: bb0210 article-title: Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells publication-title: J. Biochem. Mol. Toxicol. contributor: fullname: Ma – volume: 7 start-page: 3470 year: 2008 end-page: 3479 ident: bb0335 article-title: Dithiolethiones for cancer chemoprevention: where do we stand? publication-title: Mol. Cancer Ther. contributor: fullname: Munday – volume: 281 start-page: 27251 year: 2006 end-page: 27263 ident: bb0115 article-title: Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain publication-title: J. Biol. Chem. contributor: fullname: Kong – volume: 376 start-page: 913 year: 2008 end-page: 925 ident: bb0155 article-title: Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? publication-title: J. Mol. Biol. contributor: fullname: Blank – volume: 27 start-page: 3313 year: 2008 end-page: 3328 ident: bb0665 article-title: Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer publication-title: Oncogene contributor: fullname: Chan – volume: 433 start-page: 342 year: 2005 end-page: 350 ident: bb0095 article-title: Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome publication-title: Arch. Biochem. Biophys. contributor: fullname: Yamamoto – volume: 70 start-page: 9095 year: 2010 end-page: 9105 ident: bb0410 article-title: Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway publication-title: Cancer Res. contributor: fullname: Hirohashi – volume: 30 start-page: 3275 year: 2010 end-page: 3285 ident: bb0235 article-title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 publication-title: Mol. Cell. Biol. contributor: fullname: Zhang – volume: 99 start-page: 11908 year: 2002 end-page: 11913 ident: bb0060 article-title: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Talalay – volume: 13 start-page: 76 year: 1999 end-page: 86 ident: bb0070 article-title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain publication-title: Genes Dev. contributor: fullname: Yamamoto – volume: 42 start-page: 1797 year: 2007 end-page: 1806 ident: bb0205 article-title: Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2 publication-title: Free Radic. Biol. Med. contributor: fullname: Waalkes – volume: 362 start-page: 816 year: 2007 end-page: 821 ident: bb0440 article-title: A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Nguyen – volume: 97 start-page: 12475 year: 2000 end-page: 12480 ident: bb0195 article-title: Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2 publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Pickett – volume: 24 start-page: 7681 year: 2004 end-page: 7694 ident: bb0610 article-title: Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways publication-title: Mol. Cell. Biol. contributor: fullname: Muyan – volume: 314 start-page: 268 year: 2006 end-page: 274 ident: bb0435 article-title: The consensus coding sequences of human breast and colorectal cancers publication-title: Science contributor: fullname: Velculescu – volume: 12 start-page: 486 year: 2012 end-page: 504 ident: bb0525 article-title: General molecular biology and architecture of nuclear receptors publication-title: Curr. Top. Med. Chem. contributor: fullname: Staels – volume: 132 start-page: 1033 year: 2013 end-page: 1044 ident: bb0685 article-title: The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease publication-title: J. Allergy Clin. Immunol. contributor: fullname: Cidlowski – volume: 13 start-page: 864 year: 2011 end-page: 873 ident: bb0405 article-title: NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer publication-title: Neoplasia contributor: fullname: Yamamoto – volume: 348 start-page: 411 year: 2012 end-page: 417 ident: bb0700 article-title: Structural basis for nuclear hormone receptor DNA binding publication-title: Mol. Cell. Endocrinol. contributor: fullname: Claessens – volume: 270 start-page: 139 year: 2013 end-page: 148 ident: bb0635 article-title: The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Matthews – volume: 12 start-page: 505 year: 2012 end-page: 527 ident: bb0560 article-title: Retinoid receptors and therapeutic applications of RAR/RXR modulators publication-title: Curr. Top. Med. Chem. contributor: fullname: Gronemeyer – volume: 32 start-page: 1506 year: 2012 end-page: 1517 ident: bb0245 article-title: PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function publication-title: Mol. Cell. Biol. contributor: fullname: Xia – volume: 1821 start-page: 21 year: 2012 end-page: 56 ident: bb0585 article-title: The retinoid X receptors and their ligands publication-title: Biochim. Biophys. Acta contributor: fullname: Xia – volume: 38 start-page: 5718 year: 2010 end-page: 5734 ident: bb0035 article-title: Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis publication-title: Nucleic Acids Res. contributor: fullname: Biswal – volume: 8 start-page: 105 year: 2013 end-page: 112 ident: bb0480 article-title: Aberrant Keap1 methylation in breast cancer and association with clinicopathological features publication-title: Epigenetics contributor: fullname: Parrella – volume: 124 start-page: 585 year: 2010 end-page: 591 ident: bb0630 article-title: Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer publication-title: Breast Cancer Res. Treat. contributor: fullname: Zhou – volume: 3 start-page: 950 year: 2004 end-page: 964 ident: bb0795 article-title: Principles for modulation of the nuclear receptor superfamily publication-title: Nat. Rev. Drug Discov. contributor: fullname: Laudet – volume: 3 start-page: e420 year: 2006 ident: bb0425 article-title: Dysfunctional KEAP1–NRF2 interaction in non-small-cell lung cancer publication-title: PLoS Med. contributor: fullname: Biswal – volume: 20 start-page: 397 year: 1994 end-page: 403 ident: bb0580 article-title: Chromosomal localization of the human retinoid X receptors publication-title: Genomics contributor: fullname: Evans – volume: 18 start-page: 439 year: 2011 end-page: 451 ident: bb0075 article-title: INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis publication-title: Cell Death Differ. contributor: fullname: Jaiswal – volume: 32 start-page: 4825 year: 2013 end-page: 4835 ident: bb0790 article-title: Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity publication-title: Oncogene contributor: fullname: Schafer – volume: 27 start-page: 999 year: 2010 end-page: 1013 ident: bb0030 article-title: Nrf2–Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis publication-title: Pharm. Res. contributor: fullname: Surh – volume: 66 start-page: 8293 year: 2006 end-page: 8296 ident: bb0300 article-title: Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 publication-title: Cancer Res. contributor: fullname: Kong – volume: 6 start-page: 857 year: 2001 end-page: 868 ident: bb0105 article-title: Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription publication-title: Genes Cells contributor: fullname: Yamamoto – volume: 58 start-page: 712 year: 2006 end-page: 725 ident: bb0545 article-title: International Union of Pharmacology. LX. Retinoic acid receptors publication-title: Pharmacol. Rev. contributor: fullname: Gronemeyer – volume: 116 start-page: 561 year: 2006 end-page: 570 ident: bb0720 article-title: Estrogen receptors and human disease publication-title: J. Clin. Invest. contributor: fullname: Korach – volume: 206 start-page: 100 year: 2013 end-page: 108 ident: bb0785 article-title: Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway publication-title: Chem. Biol. Interact. contributor: fullname: Chen – volume: 49 start-page: 1603 year: 2010 end-page: 1616 ident: bb0015 article-title: Oxidative stress, inflammation, and cancer: how are they linked? publication-title: Free Radic. Biol. Med. contributor: fullname: Aggarwal – volume: 65 start-page: 201 year: 2010 end-page: 205 ident: bb0590 article-title: Bexarotene: a promising anticancer agent publication-title: Cancer Chemother. Pharmacol. contributor: fullname: Tang – volume: 173 start-page: 154 year: 2001 end-page: 160 ident: bb0310 article-title: Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust publication-title: Toxicol. Appl. Pharmacol. contributor: fullname: Yamamoto – volume: 20 start-page: 3906 year: 2001 end-page: 3917 ident: bb0140 article-title: Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene publication-title: Oncogene contributor: fullname: Jaiswal – volume: 53 start-page: 409 year: 2002 end-page: 435 ident: bb0595 article-title: The mechanisms of action of PPARs publication-title: Annu. Rev. Med. contributor: fullname: Moller – volume: 482 start-page: 347 year: 2012 end-page: 355 ident: bb0255 article-title: The microcosmos of cancer publication-title: Nature contributor: fullname: Lowe – volume: 15 start-page: 3423 year: 2009 end-page: 3432 ident: bb0380 article-title: Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer publication-title: Clin. Cancer Res. contributor: fullname: Yamamoto – volume: 5 start-page: 14 year: 2006 ident: bb0005 article-title: Reactive oxygen species: role in the development of cancer and various chronic conditions publication-title: J. Carcinog. contributor: fullname: Ahsan – volume: 16 start-page: 1295 year: 2012 end-page: 1322 ident: bb0010 article-title: Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy publication-title: Antioxid. Redox Signal. contributor: fullname: Aggarwal – volume: 21 start-page: 805 year: 2008 end-page: 812 ident: bb0185 article-title: Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols publication-title: Chem. Res. Toxicol. contributor: fullname: Talalay – volume: 29 start-page: 6232 year: 2009 end-page: 6244 ident: bb0160 article-title: Structural basis of alternative DNA recognition by Maf transcription factors publication-title: Mol. Cell. Biol. contributor: fullname: Tanaka – volume: 334 start-page: 3 year: 2011 end-page: 13 ident: bb0505 article-title: What are nuclear receptor ligands? publication-title: Mol. Cell. Endocrinol. contributor: fullname: Sladek – volume: 7 start-page: 135 year: 2001 end-page: 145 ident: bb0305 article-title: Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione publication-title: Mol. Med. contributor: fullname: Kensler – volume: 145 start-page: 311 year: 2004 end-page: 317 ident: bb0620 article-title: In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens publication-title: Endocrinology contributor: fullname: Lubahn – volume: 279 start-page: 31556 year: 2004 end-page: 31567 ident: bb0120 article-title: Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron publication-title: J. Biol. Chem. contributor: fullname: Hayes – volume: 62 start-page: 5196 year: 2002 end-page: 5203 ident: bb0025 article-title: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray publication-title: Cancer Res. contributor: fullname: Biswal – volume: 28 start-page: 2758 year: 2008 end-page: 2770 ident: bb0055 article-title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 69 start-page: 8217 year: 2009 end-page: 8222 ident: bb0555 article-title: Nuclear receptor coregulators in cancer biology publication-title: Cancer Res. contributor: fullname: Kumar – volume: 56 start-page: 230 year: 2011 end-page: 234 ident: bb0455 article-title: KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma publication-title: J. Hum. Genet. contributor: fullname: Gabrielson – volume: 104 start-page: 19589 year: 2007 end-page: 19594 ident: bb0570 article-title: Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Wolf – volume: 1783 start-page: 1847 year: 2008 end-page: 1856 ident: bb0170 article-title: Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif publication-title: Biochim. Biophys. Acta contributor: fullname: Kong – volume: 220 start-page: 446 year: 2010 end-page: 451 ident: bb0400 article-title: Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin publication-title: J. Pathol. contributor: fullname: Lee – volume: 6 start-page: 793 year: 2007 end-page: 810 ident: bb0565 article-title: RAR and RXR modulation in cancer and metabolic disease publication-title: Nat. Rev. Drug Discov. contributor: fullname: Gronemeyer – volume: 58 start-page: 782 year: 2006 end-page: 797 ident: bb0680 article-title: International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors publication-title: Pharmacol. Rev. contributor: fullname: Cidlowski – volume: 24 start-page: 10941 year: 2004 end-page: 10953 ident: bb0145 article-title: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex publication-title: Mol. Cell. Biol. contributor: fullname: Hannink – volume: 12 start-page: 66 year: 2012 ident: bb0475 article-title: Methylation of the KEAP1 gene promoter region in human colorectal cancer publication-title: BMC Cancer contributor: fullname: Saijo – volume: 65 start-page: 1631 year: 2008 end-page: 1652 ident: bb0330 article-title: Curcumin: from ancient medicine to current clinical trials publication-title: Cell Mol. Life Sci. contributor: fullname: Torti – volume: 13 start-page: 220 year: 2002 end-page: 225 ident: bb0645 article-title: To ERR in the estrogen pathway publication-title: Trends Endocrinol. Metab. contributor: fullname: Giguere – volume: 24 start-page: 1078 year: 2011 end-page: 1079 ident: bb0355 article-title: NrF2 Keap1 as gatekeepers of redox homeostasis — do they prevent or cause cancer? publication-title: Pigment Cell Melanoma Res. contributor: fullname: Tew – volume: 68 start-page: 1303 year: 2008 end-page: 1309 ident: bb0430 article-title: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth publication-title: Cancer Res. contributor: fullname: Hirohashi – volume: 13 start-page: 1627 year: 2010 end-page: 1637 ident: bb0390 article-title: Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance publication-title: Antioxid. Redox Signal. contributor: fullname: Biswal – volume: 57 start-page: 119 year: 2013 end-page: 131 ident: bb0370 article-title: Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance publication-title: Free Radic. Biol. Med. contributor: fullname: Jaiswal – volume: 287 start-page: 9873 year: 2012 end-page: 9886 ident: bb0365 article-title: Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis publication-title: J. Biol. Chem. contributor: fullname: Jaiswal – volume: 13 start-page: 325 year: 2007 end-page: 337 ident: bb0660 article-title: Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis publication-title: Dev. Cell contributor: fullname: Nathans – volume: 13 start-page: 1665 year: 2010 end-page: 1678 ident: bb0040 article-title: Discovery of the negative regulator of Nrf2, Keap1: a historical overview publication-title: Antioxid. Redox Signal. contributor: fullname: Yamamoto – volume: 129 start-page: 983 year: 2011 end-page: 991 ident: bb0265 article-title: MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism publication-title: Breast Cancer Res. Treat. contributor: fullname: Zhou – volume: 28 start-page: 1485 year: 2007 end-page: 1490 ident: bb0325 article-title: Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast publication-title: Carcinogenesis contributor: fullname: Visvanathan – volume: 68 start-page: 364 year: 2008 end-page: 368 ident: bb0745 article-title: Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway publication-title: Cancer Res. contributor: fullname: Freeman – volume: 24 start-page: 1852 year: 2013 end-page: 1862 ident: bb0755 article-title: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence publication-title: Mol. Biol. Cell contributor: fullname: Galbiati – volume: 278 start-page: 52 year: 2007 end-page: 62 ident: bb0675 article-title: ERRbeta: a potent inhibitor of Nrf2 transcriptional activity publication-title: Mol. Cell. Endocrinol. contributor: fullname: Lubahn – volume: 34 start-page: 340 year: 2013 end-page: 346 ident: bb0730 article-title: Toward clinical application of the Keap1–Nrf2 pathway publication-title: Trends Pharmacol. Sci. contributor: fullname: Yamamoto – volume: 125 start-page: 1284 year: 2012 end-page: 1295 ident: bb0750 article-title: E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells publication-title: J. Cell Sci. contributor: fullname: Kim – volume: 20 start-page: 689 year: 1999 end-page: 725 ident: bb0510 article-title: Orphan nuclear receptors: from gene to function publication-title: Endocr. Rev. contributor: fullname: Giguere – volume: 21 start-page: 689 year: 2006 end-page: 700 ident: bb0420 article-title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer publication-title: Mol. Cell contributor: fullname: Yamamoto – volume: 64 start-page: 6424 year: 2004 end-page: 6431 ident: bb0295 article-title: Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis publication-title: Cancer Res. contributor: fullname: Yamamoto – volume: 12 start-page: 213 year: 2010 end-page: 223 ident: bb0225 article-title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 publication-title: Nat. Cell Biol. contributor: fullname: Yamamoto – volume: 348 start-page: 440 year: 2012 end-page: 449 ident: bb0550 article-title: Nuclear hormone receptor co-repressors: structure and function publication-title: Mol. Cell. Endocrinol. contributor: fullname: Schwabe – volume: 331 start-page: 91 year: 1988 end-page: 94 ident: bb0640 article-title: Identification of a new class of steroid hormone receptors publication-title: Nature contributor: fullname: Evans – volume: 281 start-page: 39776 year: 2006 end-page: 39784 ident: bb0740 article-title: p53 suppresses the Nrf2-dependent transcription of antioxidant response genes publication-title: J. Biol. Chem. contributor: fullname: Cimino – volume: 32 start-page: 3765 year: 2013 end-page: 3781 ident: bb0130 article-title: Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity publication-title: Oncogene contributor: fullname: Hayes – volume: 8 start-page: 438 year: 2002 end-page: 443 ident: bb0705 article-title: The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer publication-title: Clin. Cancer Res. contributor: fullname: Danenberg – volume: 475 start-page: 106 year: 2011 end-page: 109 ident: bb0350 article-title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis publication-title: Nature contributor: fullname: Tuveson – volume: 40 start-page: 7416 year: 2012 end-page: 7429 ident: bb0275 article-title: Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha publication-title: Nucleic Acids Res. contributor: fullname: Bell – volume: 280 start-page: 16891 year: 2005 end-page: 16900 ident: bb0735 article-title: Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants publication-title: J. Biol. Chem. contributor: fullname: Jaiswal – volume: 32 start-page: 514 year: 2013 end-page: 527 ident: bb0110 article-title: The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains publication-title: Oncogene contributor: fullname: Kong – volume: 27 start-page: 7511 year: 2007 end-page: 7521 ident: bb0190 article-title: Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response publication-title: Mol. Cell. Biol. contributor: fullname: Yamamoto – volume: 14 start-page: 580 year: 2004 end-page: 590 ident: bb0515 article-title: Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome publication-title: Genome Res. contributor: fullname: Wheeler – volume: 98 start-page: 3410 year: 2001 end-page: 3415 ident: bb0290 article-title: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Kensler – volume: 93 start-page: 547 year: 2009 end-page: 554 ident: bb0760 article-title: Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells publication-title: J. Anim. Physiol. Anim. Nutr. (Berl.) contributor: fullname: Rimbach – volume: 236 start-page: 313 year: 1997 end-page: 322 ident: bb0080 article-title: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Nabeshima – volume: 62 start-page: 1285 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0535 article-title: Retinoid pathway and cancer therapeutics publication-title: Adv. Drug Deliv. Rev. doi: 10.1016/j.addr.2010.07.003 contributor: fullname: Bushue – volume: 124 start-page: 585 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0630 article-title: Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-010-1023-8 contributor: fullname: Yao – volume: 27 start-page: 7511 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0190 article-title: Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00753-07 contributor: fullname: Tong – volume: 3 start-page: 950 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0795 article-title: Principles for modulation of the nuclear receptor superfamily publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd1551 contributor: fullname: Gronemeyer – volume: 57 start-page: 119 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0370 article-title: Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2012.12.014 contributor: fullname: Niture – volume: 7 start-page: 135 year: 2001 ident: 10.1016/j.bbamcr.2014.05.003_bb0305 article-title: Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione publication-title: Mol. Med. doi: 10.1007/BF03401947 contributor: fullname: Kwak – volume: 3 start-page: e420 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0425 article-title: Dysfunctional KEAP1–NRF2 interaction in non-small-cell lung cancer publication-title: PLoS Med. doi: 10.1371/journal.pmed.0030420 contributor: fullname: Singh – volume: 1823 start-page: 1841 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0165 article-title: The small MAF transcription factors MAFF, MAFG and MAFK: current knowledge and perspectives publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2012.06.012 contributor: fullname: Kannan – volume: 362 start-page: 816 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0440 article-title: A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2007.08.051 contributor: fullname: Nioi – volume: 24 start-page: 1852 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0755 article-title: Inhibition of nuclear factor-erythroid 2-related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence publication-title: Mol. Biol. Cell doi: 10.1091/mbc.E12-09-0666 contributor: fullname: Volonte – volume: 24 start-page: 7681 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0610 article-title: Single-chain estrogen receptors (ERs) reveal that the ERalpha/beta heterodimer emulates functions of the ERalpha dimer in genomic estrogen signaling pathways publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.17.7681-7694.2004 contributor: fullname: Li – volume: 413 start-page: 623 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0775 article-title: Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2011.09.014 contributor: fullname: Ohnuma – volume: 21 start-page: 1428 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0450 article-title: Association of keap1 and nrf2 genetic mutations and polymorphisms with endometrioid endometrial adenocarcinoma survival publication-title: Int. J. Gynecol. Cancer doi: 10.1097/IGC.0b013e31822d0eb2 contributor: fullname: Wong – volume: 135 start-page: 1358 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0445 article-title: Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.06.082 contributor: fullname: Shibata – volume: 32 start-page: 3765 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0130 article-title: Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity publication-title: Oncogene doi: 10.1038/onc.2012.388 contributor: fullname: Chowdhry – volume: 8 start-page: e73794 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0490 article-title: SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women publication-title: PLoS ONE doi: 10.1371/journal.pone.0073794 contributor: fullname: Okano – volume: 123 start-page: 2921 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0280 article-title: Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis publication-title: J. Clin. Invest. doi: 10.1172/JCI66353 contributor: fullname: Singh – volume: 34 start-page: 663 year: 2009 ident: 10.1016/j.bbamcr.2014.05.003_bb0215 article-title: Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response publication-title: Mol. Cell doi: 10.1016/j.molcel.2009.04.029 contributor: fullname: Chen – volume: 42 start-page: 1797 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0205 article-title: Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2 publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2007.03.001 contributor: fullname: Pi – volume: 12 start-page: 486 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0525 article-title: General molecular biology and architecture of nuclear receptors publication-title: Curr. Top. Med. Chem. doi: 10.2174/156802612799436641 contributor: fullname: Pawlak – volume: 58 start-page: 712 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0545 article-title: International Union of Pharmacology. LX. Retinoic acid receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.4.4 contributor: fullname: Germain – volume: 28 start-page: 2758 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0055 article-title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01704-07 contributor: fullname: Yamamoto – volume: 58 start-page: 685 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0495 article-title: Overview of nomenclature of nuclear receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.4.2 contributor: fullname: Germain – volume: 6 start-page: 793 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0565 article-title: RAR and RXR modulation in cancer and metabolic disease publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd2397 contributor: fullname: Altucci – volume: 69 start-page: 8217 year: 2009 ident: 10.1016/j.bbamcr.2014.05.003_bb0555 article-title: Nuclear receptor coregulators in cancer biology publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-09-2223 contributor: fullname: O'Malley – volume: 16 start-page: 1295 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0010 article-title: Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2011.4414 contributor: fullname: Gupta – volume: 93 start-page: 14960 year: 1996 ident: 10.1016/j.bbamcr.2014.05.003_bb0285 article-title: Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.93.25.14960 contributor: fullname: Venugopal – volume: 20 start-page: 3906 year: 2001 ident: 10.1016/j.bbamcr.2014.05.003_bb0140 article-title: Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene publication-title: Oncogene doi: 10.1038/sj.onc.1204506 contributor: fullname: Dhakshinamoorthy – volume: 20 start-page: 397 year: 1994 ident: 10.1016/j.bbamcr.2014.05.003_bb0580 article-title: Chromosomal localization of the human retinoid X receptors publication-title: Genomics doi: 10.1006/geno.1994.1193 contributor: fullname: Almasan – volume: 15 start-page: 3423 year: 2009 ident: 10.1016/j.bbamcr.2014.05.003_bb0380 article-title: Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer publication-title: Clin. Cancer Res. doi: 10.1158/1078-0432.CCR-08-2822 contributor: fullname: Homma – volume: 279 start-page: 31556 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0120 article-title: Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron publication-title: J. Biol. Chem. doi: 10.1074/jbc.M403061200 contributor: fullname: McMahon – volume: 13 start-page: 864 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0405 article-title: NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer publication-title: Neoplasia doi: 10.1593/neo.11750 contributor: fullname: Shibata – volume: 13 start-page: 1713 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0150 article-title: Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3221 contributor: fullname: Hayes – volume: 68 start-page: 1303 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0430 article-title: Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-5003 contributor: fullname: Ohta – volume: 314 start-page: 268 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0435 article-title: The consensus coding sequences of human breast and colorectal cancers publication-title: Science doi: 10.1126/science.1133427 contributor: fullname: Sjoblom – volume: 14 start-page: 580 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0515 article-title: Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome publication-title: Genome Res. doi: 10.1101/gr.2160004 contributor: fullname: Zhang – volume: 13 start-page: 325 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0660 article-title: Estrogen-related receptor beta/NR3B2 controls epithelial cell fate and endolymph production by the stria vascularis publication-title: Dev. Cell doi: 10.1016/j.devcel.2007.07.011 contributor: fullname: Chen – volume: 6 start-page: 857 year: 2001 ident: 10.1016/j.bbamcr.2014.05.003_bb0105 article-title: Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription publication-title: Genes Cells doi: 10.1046/j.1365-2443.2001.00469.x contributor: fullname: Katoh – volume: 13 start-page: 76 year: 1999 ident: 10.1016/j.bbamcr.2014.05.003_bb0070 article-title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain publication-title: Genes Dev. doi: 10.1101/gad.13.1.76 contributor: fullname: Itoh – volume: 26 start-page: 2887 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0090 article-title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.26.8.2887-2900.2006 contributor: fullname: Tong – volume: 236 start-page: 313 year: 1997 ident: 10.1016/j.bbamcr.2014.05.003_bb0080 article-title: An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.6943 contributor: fullname: Itoh – volume: 27 start-page: 3313 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0665 article-title: Orphan nuclear receptor estrogen-related receptor-beta suppresses in vitro and in vivo growth of prostate cancer cells via p21(WAF1/CIP1) induction and as a potential therapeutic target in prostate cancer publication-title: Oncogene doi: 10.1038/sj.onc.1210986 contributor: fullname: Yu – volume: 27 start-page: 999 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0030 article-title: Nrf2–Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis publication-title: Pharm. Res. doi: 10.1007/s11095-010-0096-8 contributor: fullname: Kundu – volume: 376 start-page: 913 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0155 article-title: Small Maf proteins in mammalian gene control: mere dimerization partners or dynamic transcriptional regulators? publication-title: J. Mol. Biol. doi: 10.1016/j.jmb.2007.11.074 contributor: fullname: Blank – volume: 220 start-page: 446 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0400 article-title: Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin publication-title: J. Pathol. doi: 10.1002/path.2653 contributor: fullname: Kim – volume: 125 start-page: 1284 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0750 article-title: E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells publication-title: J. Cell Sci. doi: 10.1242/jcs.095422 contributor: fullname: Kim – volume: 32 start-page: 4825 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0790 article-title: Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity publication-title: Oncogene doi: 10.1038/onc.2012.493 contributor: fullname: Arlt – volume: 108 start-page: 1433 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0770 article-title: Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1014275108 contributor: fullname: Ren – volume: 12 start-page: 213 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0225 article-title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 publication-title: Nat. Cell Biol. doi: 10.1038/ncb2021 contributor: fullname: Komatsu – volume: 285 start-page: 22576 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0230 article-title: p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.118976 contributor: fullname: Jain – volume: 58 start-page: 782 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0680 article-title: International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.4.9 contributor: fullname: Lu – volume: 65 start-page: 201 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0590 article-title: Bexarotene: a promising anticancer agent publication-title: Cancer Chemother. Pharmacol. doi: 10.1007/s00280-009-1140-4 contributor: fullname: Qu – volume: 285 start-page: 16782 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0220 article-title: Physical and functional interaction of sequestosome 1 with Keap1 regulates the Keap1–Nrf2 cell defense pathway publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.096545 contributor: fullname: Copple – volume: 25 start-page: 4150 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0690 article-title: Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.10.4150-4165.2005 contributor: fullname: Ki – volume: 24 start-page: 10941 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0145 article-title: Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.24.24.10941-10953.2004 contributor: fullname: Zhang – volume: 40 start-page: 7416 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0275 article-title: Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks409 contributor: fullname: Chorley – volume: 19 start-page: 557 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0600 article-title: PPARgamma signaling and metabolism: the good, the bad and the future publication-title: Nat. Med. doi: 10.1038/nm.3159 contributor: fullname: Ahmadian – volume: 145 start-page: 311 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0620 article-title: In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens publication-title: Endocrinology doi: 10.1210/en.2003-0817 contributor: fullname: Ansell – volume: 13 start-page: 1192 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0520 article-title: Recent progresses in identifying nuclear receptors and their families publication-title: Curr. Top. Med. Chem. doi: 10.2174/15680266113139990006 contributor: fullname: Xiao – volume: 281 start-page: 39776 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0740 article-title: p53 suppresses the Nrf2-dependent transcription of antioxidant response genes publication-title: J. Biol. Chem. doi: 10.1074/jbc.M605707200 contributor: fullname: Faraonio – volume: 9 start-page: 336 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0385 article-title: Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-09-0589 contributor: fullname: Zhang – volume: 20 start-page: 689 year: 1999 ident: 10.1016/j.bbamcr.2014.05.003_bb0510 article-title: Orphan nuclear receptors: from gene to function publication-title: Endocr. Rev. contributor: fullname: Giguere – volume: 73 start-page: 2199 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0250 article-title: Proteomic analysis of ubiquitin ligase KEAP1 reveals associated proteins that inhibit NRF2 ubiquitination publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-4400 contributor: fullname: Hast – volume: 121 start-page: 237 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0655 article-title: Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos publication-title: Mech. Dev. doi: 10.1016/j.mod.2004.01.006 contributor: fullname: Mitsunaga – volume: 62 start-page: 5196 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0025 article-title: Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray publication-title: Cancer Res. contributor: fullname: Thimmulappa – volume: 24 start-page: 1078 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0355 article-title: NrF2 Keap1 as gatekeepers of redox homeostasis — do they prevent or cause cancer? publication-title: Pigment Cell Melanoma Res. doi: 10.1111/j.1755-148X.2011.00913.x contributor: fullname: Tew – volume: 6 start-page: 317 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0470 article-title: Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome publication-title: Epigenetics doi: 10.4161/epi.6.3.14408 contributor: fullname: Muscarella – volume: 56 start-page: 230 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0455 article-title: KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma publication-title: J. Hum. Genet. doi: 10.1038/jhg.2010.172 contributor: fullname: Li – volume: 13 start-page: 220 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0645 article-title: To ERR in the estrogen pathway publication-title: Trends Endocrinol. Metab. doi: 10.1016/S1043-2760(02)00592-1 contributor: fullname: Giguere – volume: 65 start-page: 1631 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0330 article-title: Curcumin: from ancient medicine to current clinical trials publication-title: Cell Mol. Life Sci. doi: 10.1007/s00018-008-7452-4 contributor: fullname: Hatcher – volume: 107 start-page: 11579 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0670 article-title: The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1000102107 contributor: fullname: Onishi – volume: 482 start-page: 347 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0255 article-title: The microcosmos of cancer publication-title: Nature doi: 10.1038/nature10888 contributor: fullname: Lujambio – volume: 28 start-page: 1485 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0325 article-title: Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast publication-title: Carcinogenesis doi: 10.1093/carcin/bgm049 contributor: fullname: Cornblatt – volume: 39 start-page: 4743 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0415 article-title: Mutation of the Nrf2 gene in non-small cell lung cancer publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-011-1266-4 contributor: fullname: Hu – volume: 25 start-page: 162 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0050 article-title: BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.1.162-171.2005 contributor: fullname: Furukawa – volume: 31 start-page: 1833 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0315 article-title: Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung publication-title: Carcinogenesis doi: 10.1093/carcin/bgq105 contributor: fullname: Satoh – volume: 285 start-page: 23064 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0085 article-title: The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M110.121913 contributor: fullname: Plafker – volume: 98 start-page: 3410 year: 2001 ident: 10.1016/j.bbamcr.2014.05.003_bb0290 article-title: Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.051618798 contributor: fullname: Ramos-Gomez – volume: 104 start-page: 19589 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0570 article-title: Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0709483104 contributor: fullname: Wang – volume: 32 start-page: 687 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0320 article-title: Small molecule modulators of Keap1–Nrf2–ARE pathway as potential preventive and therapeutic agents publication-title: Med. Res. Rev. doi: 10.1002/med.21257 contributor: fullname: Magesh – volume: 206 start-page: 100 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0785 article-title: Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway publication-title: Chem. Biol. Interact. doi: 10.1016/j.cbi.2013.08.008 contributor: fullname: Gao – volume: 373 start-page: 151 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0460 article-title: Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2008.06.004 contributor: fullname: Wang – volume: 287 start-page: 6539 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0240 article-title: Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.316471 contributor: fullname: Camp – volume: 132 start-page: 1033 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0685 article-title: The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2013.09.007 contributor: fullname: Oakley – volume: 243 start-page: 27 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0625 article-title: Repression of cancer protective genes by 17beta-estradiol: ligand-dependent interaction between human Nrf2 and estrogen receptor alpha publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2005.08.002 contributor: fullname: Ansell – volume: 8 start-page: 438 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0705 article-title: The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer publication-title: Clin. Cancer Res. contributor: fullname: Brabender – volume: 116 start-page: 561 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0720 article-title: Estrogen receptors and human disease publication-title: J. Clin. Invest. doi: 10.1172/JCI27987 contributor: fullname: Deroo – volume: 12 start-page: 66 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0475 article-title: Methylation of the KEAP1 gene promoter region in human colorectal cancer publication-title: BMC Cancer doi: 10.1186/1471-2407-12-66 contributor: fullname: Hanada – volume: 7 start-page: 532 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0725 article-title: Biology of PPAR gamma in cancer: a critical review on existing lacunae publication-title: Curr. Mol. Med. doi: 10.2174/156652407781695765 contributor: fullname: Krishnan – volume: 5 start-page: 1918 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0200 article-title: Mechanism of action of isothiocyanates: the induction of ARE-regulated genes is associated with activation of ERK and JNK and the phosphorylation and nuclear translocation of Nrf2 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-05-0497 contributor: fullname: Xu – volume: 433 start-page: 342 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0095 article-title: Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome publication-title: Arch. Biochem. Biophys. doi: 10.1016/j.abb.2004.10.012 contributor: fullname: Katoh – volume: 66 start-page: 8293 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0300 article-title: Inhibition of 7,12-dimethylbenz(a)anthracene-induced skin tumorigenesis in C57BL/6 mice by sulforaphane is mediated by nuclear factor E2-related factor 2 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-06-0300 contributor: fullname: Xu – volume: 50 start-page: 1599 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0765 article-title: Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2011.03.008 contributor: fullname: Tang – volume: 388 start-page: 778 year: 1997 ident: 10.1016/j.bbamcr.2014.05.003_bb0650 article-title: Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta publication-title: Nature doi: 10.1038/42022 contributor: fullname: Luo – volume: 1821 start-page: 21 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0585 article-title: The retinoid X receptors and their ligands publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbalip.2011.09.014 contributor: fullname: Dawson – volume: 13 start-page: 1665 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0040 article-title: Discovery of the negative regulator of Nrf2, Keap1: a historical overview publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3222 contributor: fullname: Itoh – volume: 22 start-page: 66 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0360 article-title: Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming publication-title: Cancer Cell doi: 10.1016/j.ccr.2012.05.016 contributor: fullname: Mitsuishi – volume: 32 start-page: 1506 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0245 article-title: PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.06271-11 contributor: fullname: Ma – volume: 375 start-page: 203 year: 1995 ident: 10.1016/j.bbamcr.2014.05.003_bb0500 article-title: Structural determinants of nuclear receptor assembly on DNA direct repeats publication-title: Nature doi: 10.1038/375203a0 contributor: fullname: Rastinejad – volume: 18 start-page: 439 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0075 article-title: INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis publication-title: Cell Death Differ. doi: 10.1038/cdd.2010.114 contributor: fullname: Niture – volume: 97 start-page: 12475 year: 2000 ident: 10.1016/j.bbamcr.2014.05.003_bb0195 article-title: Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2 publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.220418997 contributor: fullname: Huang – volume: 105 start-page: 13568 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0395 article-title: Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0806268105 contributor: fullname: Shibata – volume: 25 start-page: 10895 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0100 article-title: The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.25.24.10895-10906.2005 contributor: fullname: Nioi – volume: 285 start-page: 8463 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0180 article-title: Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation publication-title: J. Biol. Chem. doi: 10.1074/jbc.M109.051714 contributor: fullname: Fourquet – volume: 12 start-page: 505 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0560 article-title: Retinoid receptors and therapeutic applications of RAR/RXR modulators publication-title: Curr. Top. Med. Chem. doi: 10.2174/156802612799436687 contributor: fullname: Maire – volume: 331 start-page: 91 year: 1988 ident: 10.1016/j.bbamcr.2014.05.003_bb0640 article-title: Identification of a new class of steroid hormone receptors publication-title: Nature doi: 10.1038/331091a0 contributor: fullname: Giguere – volume: 281 start-page: 27251 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0115 article-title: Nrf2 possesses a redox-sensitive nuclear exporting signal in the Neh5 transactivation domain publication-title: J. Biol. Chem. doi: 10.1074/jbc.M602746200 contributor: fullname: Li – volume: 38 start-page: 5718 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0035 article-title: Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq212 contributor: fullname: Malhotra – volume: 29 start-page: 6232 year: 2009 ident: 10.1016/j.bbamcr.2014.05.003_bb0160 article-title: Structural basis of alternative DNA recognition by Maf transcription factors publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00708-09 contributor: fullname: Kurokawa – volume: 7 start-page: e36774 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0695 article-title: Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11beta-HSD1-mediated glucocorticoid activation in hepatic cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0036774 contributor: fullname: Kratschmar – volume: 1783 start-page: 1847 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0170 article-title: Heterodimerization with small Maf proteins enhances nuclear retention of Nrf2 via masking the NESzip motif publication-title: Biochim. Biophys. Acta doi: 10.1016/j.bbamcr.2008.05.024 contributor: fullname: Li – volume: 278 start-page: 52 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0675 article-title: ERRbeta: a potent inhibitor of Nrf2 transcriptional activity publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2007.08.011 contributor: fullname: Zhou – volume: 13 start-page: 1627 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0390 article-title: Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance publication-title: Antioxid. Redox Signal. doi: 10.1089/ars.2010.3219 contributor: fullname: Singh – volume: 99 start-page: 11908 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0060 article-title: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.172398899 contributor: fullname: Dinkova-Kostova – volume: 68 start-page: 7975 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0375 article-title: RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-08-1401 contributor: fullname: Singh – volume: 129 start-page: 983 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0265 article-title: MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism publication-title: Breast Cancer Res. Treat. doi: 10.1007/s10549-011-1604-1 contributor: fullname: Yang – volume: 9 start-page: 2365 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0345 article-title: Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-10-0108 contributor: fullname: Singh – volume: 18 start-page: 1405 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0540 article-title: Regulation of gene expression by retinoids publication-title: Curr. Med. Chem. doi: 10.2174/092986711795029618 contributor: fullname: Amann – volume: 91 start-page: 9926 year: 1994 ident: 10.1016/j.bbamcr.2014.05.003_bb0020 article-title: Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.91.21.9926 contributor: fullname: Moi – volume: 21 start-page: 805 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0185 article-title: Two-step mechanism of induction of the gene expression of a prototypic cancer-protective enzyme by diphenols publication-title: Chem. Res. Toxicol. doi: 10.1021/tx7002883 contributor: fullname: Bensasson – volume: 275 start-page: 33142 year: 2000 ident: 10.1016/j.bbamcr.2014.05.003_bb0605 article-title: Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M002319200 contributor: fullname: Ikeda – volume: 73 start-page: 3097 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0135 article-title: RXRalpha inhibits the NRF2-ARE signaling pathway through a direct interaction with the Neh7 domain of NRF2 publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-12-3386 contributor: fullname: Wang – volume: 53 start-page: 409 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0595 article-title: The mechanisms of action of PPARs publication-title: Annu. Rev. Med. doi: 10.1146/annurev.med.53.082901.104018 contributor: fullname: Berger – volume: 30 start-page: 3275 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0235 article-title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00248-10 contributor: fullname: Lau – volume: 280 start-page: 16891 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0735 article-title: Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants publication-title: J. Biol. Chem. doi: 10.1074/jbc.M500166200 contributor: fullname: Dhakshinamoorthy – volume: 5 start-page: 14 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0005 article-title: Reactive oxygen species: role in the development of cancer and various chronic conditions publication-title: J. Carcinog. doi: 10.1186/1477-3163-5-14 contributor: fullname: Waris – volume: 8 start-page: 413 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0710 article-title: Role of retinoid X receptor mRNA expression in Barrett's esophagus publication-title: J. Gastrointest. Surg. doi: 10.1016/j.gassur.2004.02.007 contributor: fullname: Brabender – volume: 64 start-page: 6424 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0295 article-title: Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-04-1906 contributor: fullname: Iida – volume: 277 start-page: 36544 year: 2002 ident: 10.1016/j.bbamcr.2014.05.003_bb0045 article-title: The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm publication-title: J. Biol. Chem. doi: 10.1074/jbc.M206530200 contributor: fullname: Zipper – volume: 287 start-page: 9873 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0365 article-title: Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.312694 contributor: fullname: Niture – volume: 70 start-page: 9095 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0410 article-title: Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-10-0384 contributor: fullname: Shibata – volume: 334 start-page: 3 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0505 article-title: What are nuclear receptor ligands? publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2010.06.018 contributor: fullname: Sladek – volume: 31 start-page: 1121 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0125 article-title: SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.01204-10 contributor: fullname: Rada – volume: 7 start-page: 3470 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0335 article-title: Dithiolethiones for cancer chemoprevention: where do we stand? publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-08-0625 contributor: fullname: Zhang – volume: 8 start-page: 105 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0480 article-title: Aberrant Keap1 methylation in breast cancer and association with clinicopathological features publication-title: Epigenetics doi: 10.4161/epi.23319 contributor: fullname: Barbano – volume: 32 start-page: 514 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0110 article-title: The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains publication-title: Oncogene doi: 10.1038/onc.2012.59 contributor: fullname: Kim – volume: 475 start-page: 106 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0350 article-title: Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis publication-title: Nature doi: 10.1038/nature10189 contributor: fullname: DeNicola – volume: 286 start-page: 40725 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0270 article-title: miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.275495 contributor: fullname: Eades – volume: 58 start-page: 760 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0575 article-title: International Union of Pharmacology. LXIII. Retinoid X receptors publication-title: Pharmacol. Rev. doi: 10.1124/pr.58.4.7 contributor: fullname: Germain – volume: 116 start-page: 4338 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0260 article-title: MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease publication-title: Blood doi: 10.1182/blood-2009-04-214817 contributor: fullname: Sangokoya – volume: 34 start-page: 340 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0730 article-title: Toward clinical application of the Keap1–Nrf2 pathway publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2013.04.005 contributor: fullname: Suzuki – volume: 34 start-page: 1806 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0780 article-title: Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway publication-title: Carcinogenesis doi: 10.1093/carcin/bgt108 contributor: fullname: Gao – volume: 101 start-page: 2040 year: 2004 ident: 10.1016/j.bbamcr.2014.05.003_bb0065 article-title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0307301101 contributor: fullname: Wakabayashi – volume: 29 start-page: 1235 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0340 article-title: Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2 publication-title: Carcinogenesis doi: 10.1093/carcin/bgn095 contributor: fullname: Wang – volume: 348 start-page: 440 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0550 article-title: Nuclear hormone receptor co-repressors: structure and function publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2011.08.033 contributor: fullname: Watson – volume: 51 start-page: T61 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0615 article-title: Insight into the mechanisms of action of estrogen receptor beta in the breast, prostate, colon, and CNS publication-title: J. Mol. Endocrinol. doi: 10.1530/JME-13-0150 contributor: fullname: Dey – volume: 22 start-page: 63 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0210 article-title: Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells publication-title: J. Biochem. Mol. Toxicol. doi: 10.1002/jbt.20212 contributor: fullname: Apopa – volume: 270 start-page: 139 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0635 article-title: The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells publication-title: Toxicol. Appl. Pharmacol. doi: 10.1016/j.taap.2013.03.029 contributor: fullname: Lo – volume: 348 start-page: 411 year: 2012 ident: 10.1016/j.bbamcr.2014.05.003_bb0700 article-title: Structural basis for nuclear hormone receptor DNA binding publication-title: Mol. Cell. Endocrinol. doi: 10.1016/j.mce.2011.07.025 contributor: fullname: Helsen – volume: 33 start-page: 2402 year: 2013 ident: 10.1016/j.bbamcr.2014.05.003_bb0485 article-title: Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.00065-13 contributor: fullname: Suzuki – volume: 173 start-page: 154 year: 2001 ident: 10.1016/j.bbamcr.2014.05.003_bb0310 article-title: Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust publication-title: Toxicol. Appl. Pharmacol. doi: 10.1006/taap.2001.9176 contributor: fullname: Aoki – volume: 26 start-page: 525 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0715 article-title: Comprehensive expression analysis of retinoic acid receptors and retinoid X receptors in non-small cell lung cancer: implications for tumor development and prognosis publication-title: Carcinogenesis doi: 10.1093/carcin/bgi006 contributor: fullname: Brabender – volume: 18 start-page: 1917 year: 2005 ident: 10.1016/j.bbamcr.2014.05.003_bb0175 article-title: Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane publication-title: Chem. Res. Toxicol. doi: 10.1021/tx0502138 contributor: fullname: Hong – volume: 69 start-page: 201 year: 2007 ident: 10.1016/j.bbamcr.2014.05.003_bb0530 article-title: Nuclear receptor structure: implications for function publication-title: Annu. Rev. Physiol. doi: 10.1146/annurev.physiol.69.031905.160308 contributor: fullname: Bain – volume: 49 start-page: 1603 year: 2010 ident: 10.1016/j.bbamcr.2014.05.003_bb0015 article-title: Oxidative stress, inflammation, and cancer: how are they linked? publication-title: Free Radic. Biol. Med. doi: 10.1016/j.freeradbiomed.2010.09.006 contributor: fullname: Reuter – volume: 6 start-page: 710 year: 2011 ident: 10.1016/j.bbamcr.2014.05.003_bb0465 article-title: Frequent epigenetics inactivation of KEAP1 gene in non-small cell lung cancer publication-title: Epigenetics doi: 10.4161/epi.6.6.15773 contributor: fullname: Muscarella – volume: 93 start-page: 547 year: 2009 ident: 10.1016/j.bbamcr.2014.05.003_bb0760 article-title: Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells publication-title: J. Anim. Physiol. Anim. Nutr. (Berl.) doi: 10.1111/j.1439-0396.2008.00838.x contributor: fullname: Boesch-Saadatmandi – volume: 68 start-page: 364 year: 2008 ident: 10.1016/j.bbamcr.2014.05.003_bb0745 article-title: Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-07-2170 contributor: fullname: Brown – volume: 21 start-page: 689 year: 2006 ident: 10.1016/j.bbamcr.2014.05.003_bb0420 article-title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer publication-title: Mol. Cell doi: 10.1016/j.molcel.2006.01.013 contributor: fullname: Padmanabhan |
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| Snippet | Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays a critical role in regulating cellular defense against electrophilic and... |
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| SubjectTerms | Animals Cancer therapy Carcinogenesis - metabolism Carcinogenesis - pathology Humans KEAP1 Models, Biological Neh7 Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology NF-E2-Related Factor 2 - antagonists & inhibitors NF-E2-Related Factor 2 - metabolism NRF2 Nuclear receptor Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction |
| Title | Modulation of NRF2 signaling pathway by nuclear receptors: Implications for cancer |
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