Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells

• Published in: European journal of medicinal chemistry Vol. 141; pp. 92 - 100
• Main Authors: Wang, Tao, Jiang, Hongmei, Cao, Shijie, Chen, Qian, Cui, Mingyuan, Wang, Zhijie, Li, Dandan, Zhou, Jing, Qiu, Feng, Kang, Ning
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.12.2017
• Subjects: AMP-Activated Protein Kinases - metabolism; Antihyperglycemic effect; Baicalin; Cell Survival - drug effects; Dose-Response Relationship, Drug; Flavonoids - chemistry; Flavonoids - metabolism; Flavonoids - pharmacology; Gluconeogenesis - drug effects; Gluconeogenic genes; Hep G2 Cells; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - metabolism; Hypoglycemic Agents - pharmacology; Insulin Resistance; Insulin-Secreting Cells - drug effects; Metabolites; Molecular Structure; Proto-Oncogene Proteins c-akt - metabolism; Structure-Activity Relationship; Tumor Cells, Cultured; Gluconeogenic genes; Metabolites; Antihyperglycemic effect; Baicalin

Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is an important component of several famous Chinese medicinal formulas for treating patients with diabetes mellitus. Baicalin (BG), a main bioactive component of S. baicalensis, has been reported to have antid...