Synthesis of arctigenin derivatives against infectious hematopoietic necrosis virus

• Published in: European journal of medicinal chemistry Vol. 163; pp. 183 - 194
• Main Authors: Hu, Yang, Liu, Lei, Li, Boyang, Shen, Yufeng, Wang, Gao-Xue, Zhu, Bin
• Format: Journal Article
• Language: English
• Published: ISSY-LES-MOULINEAUX Elsevier Masson SAS 01.02.2019; Elsevier
• Subjects: Antiviral activity; Arctigenin derivatives; Chemistry, Medicinal; IHNV; Life Sciences & Biomedicine; Pharmacology & Pharmacy; Science & Technology; IHNV; Antiviral activity; Arctigenin derivatives; IN-VITRO; RAINBOW-TROUT; ANTHELMINTIC ACTIVITY; DNA VACCINE; PATHWAY; IMMUNE-RESPONSES; DACTYLOGYRUS-INTERMEDIUS

Infectious hematopoietic necrosis virus (IHNV) is a common pathogen that causes severe disease and huge economic losses in the salmonid aquaculture industry. Herein, a series of arctigenin derivatives are synthesized to evaluate their antiviral activity against IHNV. The results indicate that the le...