Point-of-care microchip electrophoresis for integrated anemia and hemoglobin variant testing

• Published in: Lab on a chip Vol. 21; no. 2; pp. 3863 - 3875
• Main Authors: An, Ran, Man, Yuncheng, Iram, Shamreen, Kucukal, Erdem, Hasan, Muhammad Noman, Huang, Yuning, Goreke, Utku, Bode, Allison, Hill, Ailis, Cheng, Kevin, Sekyonda, Zoe, Ahuja, Sanjay P, Little, Jane A, Hinczewski, Michael, Gurkan, Umut A
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 12.10.2021
• Subjects: Algorithms; Anemia; Anemia, Sickle Cell - diagnosis; Anemia, Sickle Cell - genetics; Artificial neural networks; Electrophoresis; Electrophoresis, Microchip; Female; Geographical distribution; Hematologic Tests; Hemoglobin; Hemoglobins - analysis; Hemoglobins - genetics; Humans; Learning theory; Machine learning; Point of care testing; Point-of-Care Systems; Sensitivity; Sickle cell disease

Anemia affects over 25% of the world's population with the heaviest burden borne by women and children. Genetic hemoglobin (Hb) variants, such as sickle cell disease, are among the major causes of anemia. Anemia and Hb variant are pathologically interrelated and have an overlapping geographical...