Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 50; no. 9; pp. 1385 - 1394
• Main Authors: Andari, Elissar, Gopinath, Kaundinya, O’Leary, Erin, Caceres, Gabriella A., Nishitani, Shota, Smith, Alicia K., Ousley, Opal, Rilling, James K., Cubells, Joseph F., Young, Larry J.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2025; Nature Publishing Group
• Subjects: 631/378/1457/1601; 631/477/2811; Administration, Intranasal; Adult; Adults; Autism; Autism Spectrum Disorder - diagnostic imaging; Autism Spectrum Disorder - drug therapy; Autism Spectrum Disorder - physiopathology; Behavioral Sciences; Biological Psychology; Blindness; Brain - diagnostic imaging; Brain - drug effects; Brain - physiopathology; Clinical trials; Cognition; DNA methylation; Dose-Response Relationship, Drug; Double-Blind Method; Drug dosages; Hormones; Humans; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Nerve Net - diagnostic imaging; Nerve Net - drug effects; Nerve Net - physiopathology; Neural networks; Neurosciences; Oxytocin; Oxytocin - administration & dosage; Oxytocin - pharmacology; Pharmacotherapy; Placebos; Psychiatry; Random Forest; Sensorimotor system; Within-subjects design; Young Adult

Intranasal oxytocin (IN-OXT) has shown some promises in rescuing social deficits in autism spectrum disorder (ASD) as well as some inconsistencies in long-term trials. We conducted a target engagement study to study the precise effects of different doses of IN-OXT on brain resting-state functional c...