Random forest and Shapley Additive exPlanations predict oxytocin targeted effects on brain functional networks involved in salience and sensorimotor processing, in a randomized clinical trial in autism - Andari, Elissar; Gopinath, Kaundinya; O’Leary, Erin; Caceres, Gabriella A.; Nishitani, Shota; Smith, Alicia K.; Ousley, Opal; Rilling, James K.; Cubells, Joseph F.; Young, Larry J. (Neuropsychopharmacology (New York, N.Y.), 2025)
Keywords: 631/378/1457/1601; 631/477/2811; Administration, Intranasal; Adult; Adults; Autism; Autism Spectrum Disorder - diagnostic imaging; Autism Spectrum Disorder - drug therapy; Autism Spectrum Disorder - physiopathology; Behavioral Sciences; Biological Psychology; Blindness; Brain - diagnostic imaging; Brain - drug effects; Brain - physiopathology; Clinical trials; Cognition; DNA methylation; Dose-Response Relationship, Drug; Double-Blind Method; Drug dosages; Hormones; Humans; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Nerve Net - diagnostic imaging; Nerve Net - drug effects; Nerve Net - physiopathology; Neural networks; Neurosciences; Oxytocin; Oxytocin - administration & dosage; Oxytocin - pharmacology; Pharmacotherapy; Placebos; Psychiatry; Random Forest; Sensorimotor system; Within-subjects design; Young Adult