Allogeneic nonmyeloablative hematopoietic cell transplantation in metastatic colon cancer: tumor-specific T cells directed to a tumor-associated antigen are generated in vivo during GVHD

• Published in: Blood Vol. 107; no. 9; pp. 3795 - 3803
• Main Authors: Carnevale-Schianca, Fabrizio, Cignetti, Alessandro, Capaldi, Antonio, Vitaggio, Katiuscia, Vallario, Antonella, Ricchiardi, Alberto, Sperti, Elisa, Ferraris, Renato, Gatti, Marco, Grignani, Giovanni, Rota-Scalabrini, Delia, Geuna, Massimo, Fizzotti, Marco, Sangiolo, Dario, Sottile, Antonino, De Rosa, Giovanni, Bucci, Anna Rosa, Lambertenghi-Deliliers, Giorgio, Benedetti, Edoardo, Nash, Richard, Aglietta, Massimo
• Format: Journal Article
• Language: English
• Published: Washington, DC Elsevier Inc 01.05.2006; The Americain Society of Hematology
• Subjects: Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Carcinoembryonic Antigen; Case-Control Studies; Colonic Neoplasms - immunology; Colonic Neoplasms - secondary; Colonic Neoplasms - therapy; Emergency and intensive respiratory care; Female; Gastroenterology. Liver. Pancreas. Abdomen; Graft vs Host Disease - immunology; Graft vs Tumor Effect - immunology; Hematopoietic Stem Cell Transplantation; HLA-A Antigens; HLA-A2 Antigen; Humans; In Vitro Techniques; Intensive care medicine; Male; Medical sciences; Middle Aged; Pilot Projects; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; T-Lymphocytes - immunology; Transplantation Chimera - immunology; Transplantation, Homologous; Tumors; Human; Immunopathology; Tumor associated antigen; Graft versus tumor reaction; Stem cell; Hematopoietic cell; Homograft; Graft versus host reaction; Non myeloablative treatment; Metastasis; Malignant tumor; Colonic disease; Carcinoembryonic antigen; In vivo; Colon cancer; Treatment; T-Lymphocyte; Digestive diseases; Graft; Intestinal disease; Advanced stage

A pilot study was conducted to evaluate safety and activity of nonmyeloablative allogeneic hematopoietic cell transplantation (HCT) in colorectal carcinoma (CRC) and to determine whether a T-cell response to a tumor-associated antigen (TAA) was induced. Fifteen patients with metastatic CRC underwent...