Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization - Wang, Guangcheng; Liu, Wenjing; Peng, Zhiyun; Huang, Yong; Gong, Zipeng; Li, Yongjun (Bioorganic chemistry, 2020)
Keywords: Anticancer; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biochemistry & Molecular Biology; Cell Proliferation - drug effects; Chemistry; Chemistry, Organic; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Life Sciences & Biomedicine; MCF-7 Cells; Models, Molecular; Molecular Structure; Naphthalene; Naphthalenes - chemistry; Naphthalenes - pharmacology; Physical Sciences; Polymerization - drug effects; Pyrazole; Pyrazoles - chemistry; Pyrazoles - pharmacology; Science & Technology; Structure-Activity Relationship; Tubulin - metabolism; Tubulin polymerization inhibitor; Naphthalene; Anticancer; Tubulin polymerization inhibitor; Pyrazole; TARGET; CHALCONE DERIVATIVES; DOCKING