A standardization of the Novelty-Suppressed Feeding Test protocol in rats

• Published in: Neuroscience letters Vol. 658; pp. 73 - 78
• Main Authors: Blasco-Serra, Arantxa, González-Soler, Eva M., Cervera-Ferri, Ana, Teruel-Martí, Vicent, Valverde-Navarro, Alfonso A.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 29.09.2017
• Subjects: Animal model; Animals; Antidepressive Agents - pharmacology; Depression; Depression - drug therapy; Depressive Disorder - drug therapy; Desvenlafaxine; Disease Models, Animal; Duloxetine; Duloxetine Hydrochloride - pharmacology; Exploratory Behavior - drug effects; Male; Novelty-Suppressed Feeding Test; Rats, Sprague-Dawley; Reproducibility of Results; Reserpine; Reserpine - pharmacology; Animal model; NIHT; Novelty-Suppressed Feeding Test; NSFT; SNRIs; RES-VEH; Depression; Desvenlafaxine; RES-DUL; Duloxetine; RES-DVX; Reserpine

•A normalization of Novelty Suppressed-Feeding Test methodology is proposed.•Factors such as the deprivation protocol and the highly palatable type of food widely vary in studies using NSFT.•A gradual food deprivation protocol and the increase of palatability of food are the key factors in the stand...