Integrating in vitro and in silico approaches to evaluate the “dual functionality” of palmatine chloride in inhibiting and disassembling Tau-derived VQIVYK peptide fibrils - Haj, Esraa; Losev, Yelena; Guru KrishnaKumar, V.; Pichinuk, Edward; Engel, Hamutal; Raveh, Avi; Gazit, Ehud; Segal, Daniel (Biochimica et biophysica acta, 2018)
Keywords: Adrenal Gland Neoplasms - pathology; Aggregation modulator; Amyloid; Amyloid - drug effects; Amyloid - ultrastructure; Berberine Alkaloids - pharmacology; Circular Dichroism; Computer Simulation; High-Throughput Screening; High-Throughput Screening Assays; Humans; In Vitro Techniques; Molecular Docking Simulation; Palmatine; Peptide Fragments - chemistry; Peptide Fragments - drug effects; Pheochromocytoma - pathology; PHF6 peptide; Protein Aggregation, Pathological; Tau protein; tau Proteins - chemistry; tau Proteins - drug effects; Tumor Cells, Cultured; Palmatine; High-Throughput Screening; Amyloid; PHF6 peptide; Aggregation modulator; Tau protein