The effect of sevoflurane and desflurane on markers of oxidative status in erythrocyte

• Published in: Toxicology and industrial health Vol. 27; no. 2; pp. 181 - 186
• Main Authors: Türkan, H., Aydin, A., Sayal, A., Karahalil, B.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2011; Sage Publications Ltd
• Subjects: Adult; Anesthesia; Antioxidants; Antioxidants - analysis; Biomarkers; Enzymes; Erythrocytes; Erythrocytes - drug effects; Erythrocytes - enzymology; Female; General anesthesia; Glutathione Peroxidase - analysis; Heart rate; Humans; Isoflurane - analogs & derivatives; Isoflurane - blood; Isoflurane - pharmacology; Lipid Peroxidation; Magnesium; Magnesium - analysis; Male; Malondialdehyde - analysis; Markers; Methyl Ethers - blood; Methyl Ethers - pharmacology; Oxidation-Reduction; Oxidative Stress; Patients; Pharmacy; Sod; Superoxide Dismutase - analysis; Surgery; Toxicology; Zinc; Zinc - analysis; Ankara Turkey; Turkey; Zn; Desflurane; superoxide dismutase; oxidative status; malonaldehyde; sevoflurane; Mg; glutathione peroxidase
• ISSN: 0748-2337; 1477-0393
• DOI: 10.1177/0748233710384911

The aim of our study was to evaluate the markers of oxidative status of erythrocyte during general anesthesia and compare the markers of oxidative status of erythrocyte in both sevoflurane and desflurane. Venous blood samples of patients were collected the following time intervals; initial time (IT) and first hour (1st h), first (1st day) and third days (3rd day) after anesthesia (sevoflurane and Desflurane). The levels of magnesium (Mg), zinc (Zn) as a cofactor of these enzymes, malondialdehyde (MDA) and the activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) enzymes were also determined. No significant changes were observed in these measurements when the patients were exposed to desflurane anesthesia. On the other hand, the levels of Zn on erythrocytes were significantly increased at 1st hour and 1st and 3rd days compared to initial time in sevoflurane group (p < 0.01, p < 0.01, and p < 0.05, respectively). The activity of GSH-Px was significantly increased (p = 0.05) while the activity of SOD was significantly decreased (p < 0.01) at 1st hour after administration of sevoflurane compared to the initial time. There were no changes on the levels of Mg and MDA. Our results showed that sevoflurane has more impacts on the antioxidant status of erythrocytes than desflurane.