Protein modification by thiolactone homocysteine chemistry: a multifunctionalized human serum albumin theranostic

• Published in: MedChemComm Vol. 11; no. 11; pp. 1314 - 1325
• Main Authors: Popova, Tatyana V, Krumkacheva, Olesya A, Burmakova, Anna S, Spitsyna, Anna S, Zakharova, Olga D, Lisitskiy, Vladimir A, Kirilyuk, Igor A, Silnikov, Vladimir N, Bowman, Michael K, Bagryanskaya, Elena G, Godovikova, Tatyana S
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 02.04.2020; RSC
• Subjects: Albumin; Breast cancer; Cell proliferation; Chemical compounds; Chemistry; Conjugates; Cytotoxicity; Emission spectra; Fluorescence; Glioblastoma; Homocysteine; Human serum albumin; Nitroxide; NMR; Nuclear magnetic resonance; Pharmacology; Proteins; Reagents; Serum albumin; Serum proteins; Size exclusion chromatography; Spectroscopy; Tamoxifen; Thiolactone; Toxicity; Tumor cells

As the most abundant protein with a variety of physiological functions, albumin has been used extensively for the delivery of therapeutic molecules. Thiolactone chemistry provides a powerful tool to prepare spin-labeled albumin-based multimodal imaging probes and therapeutic agents. We report the sy...