Cell division and death inhibit glassy behaviour of confluent tissues

We investigate the effects of cell division and apoptosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environme...

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Bibliographic Details
Published inSoft matter Vol. 13; no. 17; pp. 3205 - 3212
Main Authors Matoz-Fernandez, D A, Martens, Kirsten, Sknepnek, Rastko, Barrat, J L, Henkes, Silke
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 2017
Subjects
Adhesion
Adhesive strength
Apoptosis
Cell death
Cell division
Condensed Matter
Death
Dynamic tests
Materials Science
Phase diagrams
Physics
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Summary:We investigate the effects of cell division and apoptosis on collective dynamics in two-dimensional epithelial tissues. Our model includes three key ingredients observed across many epithelia, namely cell-cell adhesion, cell death and a cell division process that depends on the surrounding environment. We show a rich non-equilibrium phase diagram depending on the ratio of cell death to cell division and on the adhesion strength. For large apoptosis rates, cells die out and the tissue disintegrates. As the death rate decreases, however, we show, consecutively, the existence of a gas-like phase, a gel-like phase, and a dense confluent (tissue) phase. Most striking is the observation that the tissue is self-melting through its own internal activity, ruling out the existence of any glassy phase.
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ISSN:1744-683X
1744-6848
DOI:10.1039/c6sm02580c