Exploitation of nanoparticle-protein interactions for early disease detection

• Published in: Applied physics letters Vol. 114; no. 16
• Main Authors: Papi, Massimiliano, Palmieri, Valentina, Palchetti, Sara, Pozzi, Daniela, Digiacomo, Luca, Guadagno, Elia, del Basso De Caro, Marialaura, Di Domenico, Marina, Ricci, Serena, Pani, Roberto, Mahmoudi, Morteza, Di Carlo, Angelina, Caracciolo, Giulio
• Format: Journal Article
• Language: English
• Published: Melville American Institute of Physics 22.04.2019
• Subjects: Applied physics; Blood; Central nervous system; Change detection; Concentrators; Diagnostic software; Diagnostic systems; Lipids; Macromolecules; Nanoparticles; Proteins; Serum proteins; Tumors

The main diagnostic tools for primary and metastatic central nervous system (CNS) tumors are the anamnestic neurological examination and the imaging tests, which are expensive and lack specificity. In recent years, the shell of macromolecules which forms on nanoparticles (NPs) when they are exposed...