MiR-34a/sirtuin-1/foxo3a is involved in genistein protecting against ox-LDL-induced oxidative damage in HUVECs

• Published in: Toxicology letters Vol. 277; pp. 115 - 122
• Main Authors: Zhang, Huaping, Zhao, Zhenxiang, Pang, Xuefen, Yang, Jian, Yu, Haixia, Zhang, Yinhong, Zhou, Hui, Zhao, Jiahui
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 05.08.2017
• Subjects: Acetylation; Active Transport, Cell Nucleus; Antioxidants - pharmacology; Atherosclerosis; Catalase - metabolism; Cells, Cultured; Cytoprotection; Dose-Response Relationship, Drug; Forkhead Box Protein O3 - genetics; Forkhead Box Protein O3 - metabolism; foxo3a; Genistein; Genistein - pharmacology; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Human Umbilical Vein Endothelial Cells - drug effects; Human Umbilical Vein Endothelial Cells - enzymology; Human Umbilical Vein Endothelial Cells - pathology; Humans; Lipoproteins, LDL - toxicity; MicroRNAs - genetics; MicroRNAs - metabolism; miR-34a; Oxidative damage; Oxidative Stress - drug effects; RNA Interference; Signal Transduction - drug effects; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Sirtuin-1; Superoxide Dismutase - metabolism; Transfection; Sirtuin-1; foxo3a; Oxidative damage; miR-34a; Genistein; Atherosclerosis

•The antioxidation of genistein was correlated with the upregulation of sirtuin-1 via inhibiting miR-34a.•The antioxidation of genistein was associated with miR-34a/sirtuin-1-mediated nuclear translocation and deacetylation of foxo3a, accompanying with the enhanced expressions of MnSOD and CAT.•MiR-...