Charge-driven tripod somersault on DNA for ratiometric fluorescence imaging of small molecules in the nucleus

• Published in: Chemical science (Cambridge) Vol. 1; no. 43; pp. 153 - 164
• Main Authors: Wang, Kang-Nan, Cao, Qian, Liu, Liu-Yi, Zhao, Zi-Jian, Liu, Wenting, Zhou, Dan-Jie, Tan, Cai-Ping, Xia, Wei, Ji, Liang-Nian, Mao, Zong-Wan
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.11.2019; Royal Society of Chemistry
• Subjects: Binding; Biocompatibility; Biological activity; Chemistry; Chemistry, Multidisciplinary; Crystallography; Deoxyribonucleic acid; Derivatives; DNA; Fluorescent indicators; Imaging; Physical Sciences; Science & Technology; Selectivity; Strategy; Titration; Toxicity; Tracing; SO2 DERIVATIVES; OXIDATIVE STRESS; LIVE-CELL; HYDROGEN-PEROXIDE; SENSORS; BISULFITE; PROBE; SULFUR-DIOXIDE DERIVATIVES; LIVING CELLS; SULFIDE
• ISSN: 2041-6520; 2041-6539
• DOI: 10.1039/c9sc03594j

Although fluorescence tracing of small bioactive molecules in living cells has been extensively studied, it is still a challenging task to detect their variations in the nucleus mainly due to the impermeable nuclear membrane and nucleic acid interference. Herein, we take advantage of the nucleic aci...