Metabolism of Natriuretic peptides and impact on insulin resistance and fat mass in healthy subjects

• Published in: Clinical biochemistry Vol. 136; p. 110893
• Main Authors: Prickett, Timothy C.R., Lewis, Lynley K., Pearson, John F., Espiner, Eric A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2025
• Subjects: Adipose Tissue - metabolism; Adult; ANP; Atrial Natriuretic Factor - blood; Atrial Natriuretic Factor - metabolism; BNP; CNP; Female; Healthy Volunteers; Humans; Insulin Resistance; Male; Middle Aged; Natriuretic Peptide, Brain - blood; Natriuretic Peptide, Brain - metabolism; Natriuretic Peptides - blood; Natriuretic Peptides - metabolism; NPR-C; Obesity - blood; Obesity - metabolism; Osteocrin; Peptide Fragments - blood; Peptide Fragments - metabolism; Insulin resistance; Osteocrin; ANP; CNP; BNP; NPR-C

•Reduced natriuretic peptides (NP) associate with insulin resistance (IR) in obesity.•Whether due to higher clearance or altered molecular forms is unknown.•In a community study we find clearance does not account for lower levels.•Bioinactive NTproANP and NTproBNP outperform bioactive ANP and BNP in...