Dynamics of Multisystem Inflammatory Syndrome in Children (MIS-C) associated to COVID-19: steady severity despite declining cases and new SARS-CoV-2 variants—a single-center cohort study

• Published in: European journal of pediatrics Vol. 184; no. 6; p. 327
• Main Authors: Carzaniga, Thomas, Calcaterra, Valeria, Casiraghi, Luca, Inzani, Tommaso, Carelli, Stephana, Del Castillo, Gabriele, Cereda, Danilo, Zuccotti, Gianvincenzo, Buscaglia, Marco
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 07.05.2025; Springer Nature B.V
• Subjects: Adolescent; Antibodies, Viral - blood; Biosensors; Child; Child, Preschool; Children; COVID-19; COVID-19 - complications; COVID-19 - diagnosis; COVID-19 - epidemiology; COVID-19 - virology; Epidemiology; Female; Fingerprinting; Humans; Infant; Infections; Inflammatory diseases; Italy - epidemiology; Male; Medicine; Medicine & Public Health; Multisystem inflammatory syndrome in children; Pandemics; Pediatrics; Retrospective Studies; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Severity of Illness Index; Systemic Inflammatory Response Syndrome - diagnosis; Systemic Inflammatory Response Syndrome - epidemiology; Systemic Inflammatory Response Syndrome - virology; Italy; Infection; SARS-CoV-2; Label-free microarray biosensor; Multisystem inflammatory syndrome; Variants of concern; Children; Serum antibody fingerprint

Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition associated with SARS-CoV-2 infection. The relationship between SARS-CoV-2 variants of concern (VOCs) and the occurrence and severity of MIS-C is unknown. We analyzed the dynamics of MIS-C in the Milan metropolitan area (Ita...