Changes of respiratory microbiota associated with prognosis in pulmonary infection patients with invasive mechanical ventilation-supported respiratory failure

• Published in: Annals of medicine (Helsinki) Vol. 57; no. 1; p. 2514093
• Main Authors: Sun, Yong, Guo, Kai, Tang, Jing, Zhao, Junjie, Zhang, Xiaojing, Yan, Youqin, Yuan, Lingmin, Zhang, Yi, Qiu, Canhu, Luo, Jian, Zhang, Weiwen, Fang, Honglong, Chen, Juan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Aged; Anti-Bacterial Agents - therapeutic use; Female; High-Throughput Nucleotide Sequencing; Humans; Infectious Diseases; Intensive Care Units - statistics & numerical data; Invasive mechanical ventilation; lung microbial; Male; metagenomic next-generation sequencing; Microbiota - genetics; Middle Aged; Prognosis; pulmonary infection; Respiration, Artificial - adverse effects; Respiration, Artificial - methods; respiratory failure; Respiratory Insufficiency - microbiology; Respiratory Insufficiency - mortality; Respiratory Insufficiency - therapy; Respiratory Tract Infections - microbiology; Respiratory Tract Infections - mortality; Retrospective Studies; Risk Factors; respiratory failure; pulmonary infection; metagenomic next-generation sequencing; Invasive mechanical ventilation; lung microbial

Respiratory failure (RF) is an important cause of intensive care unit (ICU) admission and mortality due to respiratory diseases. This study aimed to evaluate the clinical performance of metagenomic next-generation sequencing (mNGS) testing in pathogen diagnosis, medication guidance and to explore dy...