Tumor clone dynamics in lethal prostate cancer

• Published in: Science translational medicine Vol. 6; no. 254; p. 254ra125
• Main Authors: Carreira, Suzanne, Romanel, Alessandro, Goodall, Jane, Grist, Emily, Ferraldeschi, Roberta, Miranda, Susana, Prandi, Davide, Lorente, David, Frenel, Jean-Sebastien, Pezaro, Carmel, Omlin, Aurelius, Rodrigues, Daniel Nava, Flohr, Penelope, Tunariu, Nina, S de Bono, Johann, Demichelis, Francesca, Attard, Gerhardt
• Format: Journal Article
• Language: English
• Published: United States 17.09.2014
• Subjects: Adult; Aged; Aged, 80 and over; Chromosome Deletion; Clone Cells; DNA Copy Number Variations; Glucocorticoids - administration & dosage; Humans; Male; Middle Aged; Mutation; Prostatic Neoplasms - genetics; Prostatic Neoplasms - pathology; Receptors, Androgen - genetics; Trans-Activators - genetics; Transcriptional Regulator ERG

It is unclear whether a single clone metastasizes and remains dominant over the course of lethal prostate cancer. We describe the clonal architectural heterogeneity at different stages of disease progression by sequencing serial plasma and tumor samples from 16 ERG-positive patients. By characterizi...