Expression of Epidermal Growth Factor and Epidermal Growth Factor Receptor Immunoreactivity in the Asthmatic Human Airway

• Published in: American journal of respiratory and critical care medicine Vol. 157; no. 6; pp. 1907 - 1912
• Main Authors: AMISHIMA, MASARU, MUNAKATA, MITSURU, NASUHARA, YASUYUKI, SATO, ATSUKO, TAKAHASHI, TORU, HOMMA, YUKIHIKO, KAWAKAMI, YOSHIKAZU
• Format: Journal Article
• Language: English
• Published: New York, NY American Lung Association 01.06.1998
• Subjects: Adult; Aged; Aged, 80 and over; Asthma - metabolism; Asthma - pathology; Basement Membrane - chemistry; Basement Membrane - pathology; Biological and medical sciences; Bronchi - chemistry; Bronchi - pathology; Chronic obstructive pulmonary disease, asthma; Epidermal Growth Factor - analysis; Epidermal Growth Factor - immunology; Epithelium - chemistry; Epithelium - pathology; Female; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Muscle, Smooth - chemistry; Muscle, Smooth - pathology; Pneumology; Receptor, Epidermal Growth Factor - analysis; Receptor, Epidermal Growth Factor - immunology; Human; Immunohistochemistry; Pathophysiology; Respiratory disease; Pathogenesis; Inflammation; Gene expression; Asthma; Respiratory tract; Pathology; Epidermal growth factor; Spatial distribution; Bronchus disease; Adult; Obstructive pulmonary disease; Biological receptor

Chronic airway inflammation, one of the pathophysiologic features of bronchial asthma, is suspected to be responsible for irreversible pathological changes of airways, called airway remodeling. To examine the mechanisms of airway remodeling in asthma, we investigated the expression of epidermal grow...