Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silico

• Published in: Human vaccines & immunotherapeutics Vol. 21; no. 1; p. 2526873
• Main Authors: Kuroda, Daisuke, Moriyama, Saya, Sasaki, Hiroaki, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Animals; Antibodies, Neutralizing - immunology; Antibodies, Viral - immunology; antibody; B-cell; Broadly Neutralizing Antibodies - immunology; Computer Simulation; Coronavirus; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - immunology; Epitopes - immunology; germline gene; Humans; repertoire; Review; SARS-CoV-2; SARS-CoV-2 - immunology; Spike Glycoprotein, Coronavirus - immunology; vaccine; SARS-CoV-2; vaccine; antibody; B-cell; germline gene; computational design; repertoire

Since the emergence of SARS-CoV-2, the ongoing arms race between mutating viruses and human antibodies has revealed several novel strategies by which antibodies adapt to viral escape. While SARS-CoV-2 viruses exhibit high variability in epitopes targeted by neutralizing antibodies, certain epitopes...