Structural dynamics of DNA unwinding by a replicative helicase

• Published in: Nature (London) Vol. 641; no. 8061; pp. 240 - 249
• Main Authors: Shahid, Taha, Danazumi, Ammar U., Tehseen, Muhammad, Alhudhali, Lubna, Clark, Alice R., Savva, Christos G., Hamdan, Samir M., De Biasio, Alfredo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2025; Nature Publishing Group
• Subjects: 101/28; 631/45/173; 631/535/1258/1259; 82/16; 82/29; 82/80; 82/83; Adenosine Triphosphate - metabolism; Clinical trials; Cryoelectron Microscopy; DNA - chemistry; DNA - metabolism; DNA - ultrastructure; DNA Helicases - chemistry; DNA Helicases - metabolism; DNA Helicases - ultrastructure; DNA Replication; Entropy; Heart failure; Humanities and Social Sciences; Hydrolysis; Models, Molecular; multidisciplinary; Nucleic Acid Conformation; Replication Origin - genetics; Science; Science (multidisciplinary); Simian virus 40 - enzymology; Stem cells; Task forces; United States > US; Japan

Hexameric helicases are nucleotide-driven molecular machines that unwind DNA to initiate replication across all domains of life. Despite decades of intensive study, several critical aspects of their function remain unresolved 1 : the site and mechanism of DNA strand separation, the mechanics of unwi...