Pnky Modulates Neural Stem Cell Proliferation and Differentiation Through Activation of Wnt/β-Catenin Signaling Pathway

• Published in: Organogenesis Vol. 21; no. 1; p. 2519641
• Main Authors: Wu, Haidong, Huang, Jing, Li, Xiaojing, Song, Yali, Chen, Xuxiang, Guo, Yajie
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.12.2025; Taylor & Francis Group
• Subjects: Animals; beta Catenin - metabolism; Cell Differentiation - genetics; Cell Proliferation; Gene Knockdown Techniques; Mice; Neural Stem Cells - cytology; Neural Stem Cells - metabolism; Neurological diseases; Neurons - cytology; Neurons - metabolism; NSC; NSC differentiation and proliferation; Pnky; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Wnt Signaling Pathway - genetics; Wnt/β-catenin pathway; Neurological diseases; NSC differentiation and proliferation; Pnky; Wnt/β-catenin pathway; NSC

Neural stem cell (NSC) possess the essential properties of pluripotency and self-renewal, making them promising candidates for the treatment of neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), and spinal cord injuries. While previous studies have identifie...