Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model

• Published in: Laboratory investigation Vol. 103; no. 4; p. 100050
• Main Authors: Kunoki, Shunnosuke, Tatsukawa, Hideki, Sakai, Yukinao, Kinashi, Hiroshi, Kariya, Tetsuyoshi, Suzuki, Yasuhiro, Mizuno, Masashi, Yamaguchi, Makoto, Sasakura, Hiroyuki, Ikeno, Masashi, Takeuchi, Kosei, Ishimoto, Takuji, Hitomi, Kiyotaka, Ito, Yasuhiko
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2023
• Subjects: Actins - metabolism; Animals; Chlorhexidine - adverse effects; Chlorhexidine - metabolism; chlorhexidine-induced model; EndMT; Endothelial Cells - metabolism; Fibrosis; Inflammation - metabolism; Mice; Mice, Knockout; peritoneal fibrosis; Peritoneal Fibrosis - chemically induced; Peritoneal Fibrosis - metabolism; Peritoneal Fibrosis - prevention & control; Peritoneum - pathology; Protein Glutamine gamma Glutamyltransferase 2; Rats; TGF-β1; Transforming Growth Factor beta - metabolism; Transforming Growth Factor beta1 - metabolism; transglutaminase; Vascular Endothelial Growth Factor A - metabolism; α-SMA; peritoneal fibrosis; α-SMA; transglutaminase; TGF-β1; EndMT; chlorhexidine-induced model

Long-term peritoneal dialysis (PD) is often associated with peritoneal dysfunction leading to withdrawal from PD. The characteristic pathologic features of peritoneal dysfunction are widely attributed to peritoneal fibrosis and angiogenesis. The detailed mechanisms remain unclear, and treatment targ...