Takotsubo syndrome: State-of-the-art review by an expert panel – Part 1

• Published in: Cardiovascular revascularization medicine Vol. 20; no. 1; pp. 70 - 79
• Main Authors: Dias, Andre, Núñez Gil, Ivan J., Santoro, Francesco, Madias, John E., Pelliccia, Francesco, Brunetti, Natale Daniele, Salmoirago-Blotcher, Elena, Sharkey, Scott W., Eitel, Ingo, Akashi, Yoshihiro J., El-Battrawy, Ibrahim, Franco, Emiliana, Akin, Ibrahim, Jaguszewski, Milosz, Dawson, Dana, Figueredo, Vincent M., Napp, L. Christian, Christensen, Thomas Emil, Hebert, Kathy, Ben-Dor, Itsik, Ozaki, Yuichi, García-Garcia, Héctor M., Kajita, Alexandre H., Akasaka, Takashi, Kurisu, Satoshi, Lerman, Amir, Waksman, Ron
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2019
• Subjects: Catecholamine; Heart failure; Humans; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Takotsubo; Takotsubo Cardiomyopathy - diagnostic imaging; Takotsubo Cardiomyopathy - epidemiology; Takotsubo Cardiomyopathy - physiopathology; Takotsubo Cardiomyopathy - therapy; Ventricular Function, Left; CRP; Heart failure; RV; BNP; LV; Catecholamine; miRs; ACS; Takotsubo; TTS; MACE; TIMI; STEMI
• ISSN: 1553-8389; 1878-0938
• DOI: 10.1016/j.carrev.2018.11.015

Takotsubo syndrome (TTS) is an acute cardiac condition independent of epicardial coronary obstruction that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities. This consensus paper is the result of a multinational effort aiming to summarize the current state of the art on TTS. Experts in the field provide a thorough and detailed review of this syndrome. Several novel and unique sections are emphasized in this document, including the current state of the art on genetics of takotsubo syndrome, microRNAs (miRs), racial differences, role of cardiac spectroscopy and intracoronary imaging, as well as mechanical circulatory support. In part 1 of this two-part manuscript, we discuss how TTS came to be known, several patterns and forms it can take in patients, epidemiology and pathophysiology of the syndrome, and clinical presentation. •Takotsubo syndrome was first described in 1986.•TTS mimics ACS and is characterized by acute heart failure.•International experts provide a thorough review of TTS.