A bioinspired flexible organic artificial afferent nerve

Sensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the tools and materials of organic electronics, Kim et al. combined a pressure sensor, a ring oscillator, and an ion gel–gated transistor to form an artificial mechan...

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Published inScience (American Association for the Advancement of Science) Vol. 360; no. 6392; pp. 998 - 1003
Main Authors Kim, Yeongin, Chortos, Alex, Xu, Wentao, Liu, Yuxin, Oh, Jin Young, Son, Donghee, Kang, Jiheong, Foudeh, Amir M., Zhu, Chenxin, Lee, Yeongjun, Niu, Simiao, Liu, Jia, Pfattner, Raphael, Bao, Zhenan, Lee, Tae-Woo
Format Journal Article
LanguageEnglish
Published United States The American Association for the Advancement of Science 01.06.2018
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Abstract Sensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the tools and materials of organic electronics, Kim et al. combined a pressure sensor, a ring oscillator, and an ion gel–gated transistor to form an artificial mechanoreceptor (see the Perspective by Bartolozzi). The combination allows for the sensing of multiple pressure inputs, which can be converted into a sensor signal and used to drive the motion of a cockroach leg in an oscillatory pattern. Science , this issue p. 998 ; see also p. 966 Organic flexible electronics mimic the functions of a biological afferent nerve and actuate muscles. The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.
AbstractList I've got a feelingSensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the tools and materials of organic electronics, Kim et al. combined a pressure sensor, a ring oscillator, and an ion gel–gated transistor to form an artificial mechanoreceptor (see the Perspective by Bartolozzi). The combination allows for the sensing of multiple pressure inputs, which can be converted into a sensor signal and used to drive the motion of a cockroach leg in an oscillatory pattern.Science, this issue p. 998; see also p. 966The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.
Sensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the tools and materials of organic electronics, Kim et al. combined a pressure sensor, a ring oscillator, and an ion gel–gated transistor to form an artificial mechanoreceptor (see the Perspective by Bartolozzi). The combination allows for the sensing of multiple pressure inputs, which can be converted into a sensor signal and used to drive the motion of a cockroach leg in an oscillatory pattern. Science , this issue p. 998 ; see also p. 966 Organic flexible electronics mimic the functions of a biological afferent nerve and actuate muscles. The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.
The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.
The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible organic electronics to mimic the functions of a sensory nerve. Our artificial afferent nerve collects pressure information (1 to 80 kilopascals) from clusters of pressure sensors, converts the pressure information into action potentials (0 to 100 hertz) by using ring oscillators, and integrates the action potentials from multiple ring oscillators with a synaptic transistor. Biomimetic hierarchical structures can detect movement of an object, combine simultaneous pressure inputs, and distinguish braille characters. Furthermore, we connected our artificial afferent nerve to motor nerves to construct a hybrid bioelectronic reflex arc to actuate muscles. Our system has potential applications in neurorobotics and neuroprosthetics.
Author Niu, Simiao
Kim, Yeongin
Liu, Yuxin
Kang, Jiheong
Zhu, Chenxin
Bao, Zhenan
Oh, Jin Young
Foudeh, Amir M.
Xu, Wentao
Lee, Yeongjun
Lee, Tae-Woo
Son, Donghee
Liu, Jia
Chortos, Alex
Pfattner, Raphael
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  givenname: Yeongin
  orcidid: 0000-0002-9495-3165
  surname: Kim
  fullname: Kim, Yeongin
  organization: Department of Electrical Engineering, Stanford University, Stanford, CA, USA
– sequence: 2
  givenname: Alex
  surname: Chortos
  fullname: Chortos, Alex
  organization: Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA
– sequence: 3
  givenname: Wentao
  orcidid: 0000-0002-1054-6037
  surname: Xu
  fullname: Xu, Wentao
  organization: Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea., Institute of Photoelectronic Thin Film Devices and Technology, Nankai University, Tianjin, China
– sequence: 4
  givenname: Yuxin
  surname: Liu
  fullname: Liu, Yuxin
  organization: Department of Bioengineering, Stanford University, Stanford, CA, USA
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  givenname: Jin Young
  orcidid: 0000-0003-2260-9960
  surname: Oh
  fullname: Oh, Jin Young
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA., Department of Chemical Engineering, Kyung Hee University, Yongin, South Korea
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  givenname: Donghee
  surname: Son
  fullname: Son, Donghee
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
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  surname: Kang
  fullname: Kang, Jiheong
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
– sequence: 8
  givenname: Amir M.
  surname: Foudeh
  fullname: Foudeh, Amir M.
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
– sequence: 9
  givenname: Chenxin
  surname: Zhu
  fullname: Zhu, Chenxin
  organization: Department of Electrical Engineering, Stanford University, Stanford, CA, USA
– sequence: 10
  givenname: Yeongjun
  orcidid: 0000-0002-2488-9903
  surname: Lee
  fullname: Lee, Yeongjun
  organization: Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea
– sequence: 11
  givenname: Simiao
  surname: Niu
  fullname: Niu, Simiao
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
– sequence: 12
  givenname: Jia
  orcidid: 0000-0003-2217-6982
  surname: Liu
  fullname: Liu, Jia
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
– sequence: 13
  givenname: Raphael
  orcidid: 0000-0002-7232-1845
  surname: Pfattner
  fullname: Pfattner, Raphael
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
– sequence: 14
  givenname: Zhenan
  orcidid: 0000-0002-0972-1715
  surname: Bao
  fullname: Bao, Zhenan
  organization: Department of Chemical Engineering, Stanford University, Stanford, CA, USA
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  givenname: Tae-Woo
  orcidid: 0000-0002-6449-6725
  surname: Lee
  fullname: Lee, Tae-Woo
  organization: Department of Materials Science and Engineering, Seoul National University, Seoul, South Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29853682$$D View this record in MEDLINE/PubMed
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Snippet Sensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the tools and materials...
The distributed network of receptors, neurons, and synapses in the somatosensory system efficiently processes complex tactile information. We used flexible...
I've got a feelingSensory (or afferent) nerves bring sensations of touch, pain, or temperature variation to the central nervous system and brain. Using the...
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SubjectTerms Afferent Pathways
Anatomy
Bioelectricity
Biomimetic Materials
Biomimetics
Braille
Brain
Central nervous system
Computer networks
Electronics
Information processing
Mechanoreceptors
Motor Neurons
Muscle Contraction
Muscles
Muscles - innervation
Muscles - physiology
Nerves
Neural Prostheses
Oscillators
Pain
Pressure
Pressure sensors
Prosthetics
Receptors
Robotics
Sensory neurons
Somatosensory system
Structural hierarchy
Synapses
Transistors
Title A bioinspired flexible organic artificial afferent nerve
URI https://www.ncbi.nlm.nih.gov/pubmed/29853682
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