Buccal micronucleus cytome assay to evaluate cyto-genotoxic effects of occupational exposure to antineoplastic drugs: application on a large sample size of workers furnished by an Italian network of oncological hospitals

• Published in: Archives of toxicology Vol. 99; no. 8; pp. 3429 - 3441
• Main Authors: Ursini, C. L., Omodeo-Salè, E., Di Gennaro, G., Buresti, G., Fresegna, A. M., Ciervo, A., Gentile, M., Maiello, R., Beltramini, S., Gaggero, D., Rigamonti, N., Maccari, E., Zorzetto, G., Maiolino, P., Di Filippo, P., Bilancio, M. C., Baldo, P., Martinello, V., Di Mattia, A., Esposito, C., Nardulli, P., Laforgia, M., Cavallo, D.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2025; Springer Nature B.V
• Subjects: 5-Fluorouracil; Adult; Antineoplastic Agents - adverse effects; Antineoplastic Agents - analysis; Antineoplastic Agents - toxicity; Antineoplastic drugs; Apoptosis; Assaying; Biological Monitoring - methods; Biomarkers; Biomedical and Life Sciences; Biomedicine; Biomonitoring; Cell growth; Chemotherapy; Chromatography; Contamination; Cytokinesis; Deoxycytidine - analogs & derivatives; DNA Damage; Drugs; Environmental Health; Environmental Monitoring - methods; Environmental research; Exposure; Female; Fluorouracil; Gemcitabine; Genotoxicity; Genotoxicity and Carcinogenicity; Hospitals; Humans; Ifosfamide; Italy; Laboratories; Male; Medical personnel; Micronucleus Tests - methods; Middle Aged; Mouth Mucosa - drug effects; Mouth Mucosa - pathology; Occupational exposure; Occupational Exposure - adverse effects; Occupational Exposure - analysis; Occupational health; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Pollution control; Workplaces; Italy; Cytotoxicity; Antineoplastic drugs; Micronucleus; Genotoxicity; Buccal cells

Many antineoplastic drugs (ADs) used to treat cancer are characterized by the non-selective effect representing a possible cause of health effects in exposed workers. We established an Italian Network of seven Oncological Hospitals with the aim to evaluate, on a large size sample of workers, cyto-ge...