The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

• Published in: The Journal of biological chemistry Vol. 297; no. 3; p. 101041
• Main Authors: Russo, Lilian Cristina, Tomasin, Rebeka, Matos, Isaac Araújo, Manucci, Antonio Carlos, Sowa, Sven T., Dale, Katie, Caldecott, Keith W., Lehtiö, Lari, Schechtman, Deborah, Meotti, Flavia C., Bruni-Cardoso, Alexandre, Hoch, Nicolas Carlos
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2021; American Society for Biochemistry and Molecular Biology
• Subjects: ADP-ribosylation; COVID-19; DTX3L; macrodomain; PARP9; SARS-CoV-2; COVID-19; IFN; SARS-CoV-2; DTX3L; macrodomain; PARP; PARP9; ISG; Nsp3; ADP-ribosylation

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for coronavirus pathogenesis and is thus an attractive target for drug development. This macrodomain is thought to counteract the host interferon (IFN) response, an important antiviral signalling cascade, via the reve...