Design, synthesis, biological evaluation and molecular docking studies of new chalcone derivatives containing diaryl ether moiety as potential anticancer agents and tubulin polymerization inhibitors

• Published in: Bioorganic chemistry Vol. 95; pp. 103565 - 103572
• Main Authors: Wang, Guangcheng, Liu, Wenjing, Gong, Zipeng, Huang, Yong, Li, Yongjun, Peng, Zhiyun
• Format: Journal Article
• Language: English
• Published: SAN DIEGO Elsevier Inc 01.01.2020; Elsevier
• Subjects: Anticancer agents; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biochemistry & Molecular Biology; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Chalcone; Chalcones - chemistry; Chalcones - pharmacology; Chemistry; Chemistry, Organic; Diaryl ether; Drug Design; Drug Evaluation, Preclinical; Humans; Life Sciences & Biomedicine; Molecular Docking Simulation; Physical Sciences; Polymerization - drug effects; Science & Technology; Structure-Activity Relationship; Tubulin - chemistry; Tubulin Modulators - chemical synthesis; Tubulin Modulators - chemistry; Tubulin Modulators - pharmacology; Tubulin polymerization inhibitor; Anticancer agents; Diaryl ether; Tubulin polymerization inhibitor; Chalcone; COLCHICINE; SERIES; MICROTUBULES; TARGETING TUBULIN; ANTIMITOTIC CHALCONES
• ISSN: 0045-2068; 1090-2120; 1090-2120
• DOI: 10.1016/j.bioorg.2019.103565

[Display omitted] •Chalcone derivatives containing diaryl ether moiety were designed and synthesized.•In vitro anticancer activities were determined.•Compound 5b was found to be the most active compound.•Compound 5b inhibited tubulin polymerization.•Molecular docking studies were performed. A novel...