Evaluating the effects of diclofenac sodium and etodolac on renal hemodynamics with contrast-enhanced ultrasonography: a pilot study

• Published in: European journal of clinical pharmacology Vol. 69; no. 2; pp. 161 - 165
• Main Authors: Imamura, Hiroshi, Hata, Jiro, Iida, Ai, Manabe, Noriaki, Haruma, Ken
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.02.2013; Springer; Springer Nature B.V
• Subjects: Adult; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Clinical Trial; Cross-Over Studies; Cyclooxygenase 2 Inhibitors - administration & dosage; Diclofenac - administration & dosage; Etodolac - administration & dosage; Female; Hemodynamics - drug effects; Humans; Kidney - blood supply; Kidney - diagnostic imaging; Kidney - drug effects; Kidneys; Male; Medical sciences; Pharmacology. Drug treatments; Pharmacology/Toxicology; Renal Circulation - drug effects; Sodium; Ultrasonic technology; Ultrasonography; Etodolac; Diclofenac sodium; Non-steroidal anti-inflammatory drugs (NSAIDs); Renal blood flow (RBF); Contrast-enhanced ultrasonography; Sonography; Human; Prostaglandin-endoperoxide synthase; Enzyme; Enzyme inhibitor; Kidney; Diclofenac; Blood flow; Non steroidal antiinflammatory agent; Arylacetic acid derivatives; Analgesic; Urinary system; Sodium; Echography; Antipyretic; Oxidoreductases; Hemodynamics

Purpose Contrast-enhanced ultrasonography (CEUS) is a novel approach used for measuring organ perfusion changes. Studies using CEUS to assess the effects of non-steroidal anti-inflammatory drugs (NSAIDs) on renal blood flow (RBF) have not yet been conducted. We aimed to evaluate the effects of NSAID...