Neutrophil Extracellular Traps: The Biology of Chromatin Externalization

• Published in: Developmental cell Vol. 44; no. 5; pp. 542 - 553
• Main Authors: Sollberger, Gabriel, Tilley, Dorothea Ogmore, Zychlinsky, Arturo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.03.2018
• Subjects: antimicrobial activity; extracellular chromatin; innate immunity; NET; neutrophil; neutrophil extracellular traps; neutrophil extracellular traps; antimicrobial activity; innate immunity; NET; neutrophil; extracellular chromatin
• ISSN: 1534-5807; 1878-1551; 1878-1551
• DOI: 10.1016/j.devcel.2018.01.019

Neutrophils are essential to the homeostatic mission of safeguarding host tissues, responding rapidly and diversely to breaches of the host's barriers to infection, and returning tissues to a sterile state. In response to specific stimuli, neutrophils extrude modified chromatin structures decor...