Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality

• Published in: Nature microbiology Vol. 5; no. 12; pp. 1464 - 1471
• Main Authors: Mendenhall, Megan A., Liu, Shihui, Portley, Makayla K., O’Mard, Danielle, Fattah, Rasem, Szabo, Roman, Bugge, Thomas H., Khillan, Jaspal S., Leppla, Stephen H., Moayeri, Mahtab
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2020; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 101/1; 13; 13/106; 42/70; 45/41; 631/326/421; 631/326/88; 692/699/1785; 692/699/255; 82; 82/29; 82/58; 82/80; 82/83; 96/109; 96/34; 96/95; Amino Acid Motifs; Animals; Anthrax; Anthrax - enzymology; Anthrax - genetics; Anthrax - microbiology; Anthrax lethal toxin; Antigens, Bacterial - metabolism; Antigens, Bacterial - toxicity; Bacillus anthracis - enzymology; Bacillus anthracis - metabolism; Bacterial Toxins - metabolism; Bacterial Toxins - toxicity; Biomedical and Life Sciences; Class Ia Phosphatidylinositol 3-Kinase - chemistry; Class Ia Phosphatidylinositol 3-Kinase - genetics; Class Ia Phosphatidylinositol 3-Kinase - metabolism; Homology; Humans; Infectious Diseases; Inflammasomes; Kinases; Lethal factor; Lethality; Letter; Life Sciences; Male; MAP kinase; Medical Microbiology; Mice; Mice, Inbred C57BL; Microbiology; MKKS protein; Parasitology; Peptide Hydrolases - genetics; Peptide Hydrolases - metabolism; Phosphatidylinositol 3-Kinases - chemistry; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Proline; Protective antigen; Protein kinase; Regulatory subunits; Signal transduction; Virology

Anthrax lethal toxin (LT), produced by Bacillus anthracis , comprises a receptor-binding moiety, protective antigen and the lethal factor (LF) protease 1 , 2 . Although LF is known to cleave mitogen-activated protein kinase kinases (MEKs/MKKs) and some variants of the NLRP1 inflammasome sensor, targ...