Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to...
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| Published in | Autoimmunity reviews Vol. 18; no. 4; pp. 426 - 432 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Netherlands
Elsevier B.V
01.04.2019
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| Abstract | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE.
•The breakdown of the blood brain barrier involves the direct effect of cytokines and complement proteins.•TWEAK plays an important role in BBB disruption through the induction of cytokines in endothelial cells (ECs).•The complement protein C5a promotes a cytoskeletal remodeling that destabilizes the tight and adherens junctions of ECs.•The anti-NMDAR and anti-RP antibodies are key effectors of neuronal damage by induction of apoptosis.•The diffuse manifestations of NPSLE result in increased intrathecal production of cytokines, specially IL-6 |
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| AbstractList | Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE. Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that can involve nervous system commitment known as neuropsychiatric systemic lupus erythematosus (NPSLE). The diagnostic of NPSLE is complex because the symptoms range from focal symptoms (e.g., strokes, thrombotic events) to diffuse disorders affecting cognition, mood and level of consciousness (e.g. acute confusional state, psychosis). Both type of manifestations of NPSLE differ in their pathological mechanisms. The focus of this review will be on the mechanisms that lead to the blood-brain barrier (BBB) disruption and to the neuroinflammation related with the diffuse manifestations of NPSLE. •The breakdown of the blood brain barrier involves the direct effect of cytokines and complement proteins.•TWEAK plays an important role in BBB disruption through the induction of cytokines in endothelial cells (ECs).•The complement protein C5a promotes a cytoskeletal remodeling that destabilizes the tight and adherens junctions of ECs.•The anti-NMDAR and anti-RP antibodies are key effectors of neuronal damage by induction of apoptosis.•The diffuse manifestations of NPSLE result in increased intrathecal production of cytokines, specially IL-6 |
| Author | Ortiz-Reyes, Blanca L. Duarte-Delgado, Nancy P. Vásquez, Gloria |
| Author_xml | – sequence: 1 givenname: Nancy P. surname: Duarte-Delgado fullname: Duarte-Delgado, Nancy P. email: nancy.duarte@docentes.umb.edu.co organization: Universidad Manuela Beltrán, Departamento de Ciencias Básicas, Bogotá, Colombia – sequence: 2 givenname: Gloria surname: Vásquez fullname: Vásquez, Gloria organization: Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética-GICIG, Medellín, Colombia – sequence: 3 givenname: Blanca L. surname: Ortiz-Reyes fullname: Ortiz-Reyes, Blanca L. organization: Universidad de Antioquia, Facultad de Medicina, Grupo de Inmunología Celular e Inmunogenética-GICIG, Medellín, Colombia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30763633$$D View this record in MEDLINE/PubMed |
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| Keywords | Neuropsychiatric systemic lupus erythematosus Complement Autoantibodies Cytokines Blood-brain barrier and mechanisms |
| Language | English |
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| Title | Blood-brain barrier disruption and neuroinflammation as pathophysiological mechanisms of the diffuse manifestations of neuropsychiatric systemic lupus erythematosus |
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